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本文引用的文献

1

HIV-associated tuberculosis: clinical update.HIV 相关性结核病：临床最新进展。

Clin Infect Dis. 2010 May 15;50(10):1377-86. doi: 10.1086/652147.

2

Urine for the diagnosis of tuberculosis: current approaches, clinical applicability, and new developments.尿液检测在结核病诊断中的应用：当前方法、临床适用性及新进展。

Curr Opin Pulm Med. 2010 May;16(3):262-70. doi: 10.1097/MCP.0b013e328337f23a.

3

Clinical utility of a commercial LAM-ELISA assay for TB diagnosis in HIV-infected patients using urine and sputum samples.商业化 LAM-ELISA 检测在 HIV 感染患者中用于尿液和痰液样本的结核诊断的临床实用性。

PLoS One. 2010 Mar 24;5(3):e9848. doi: 10.1371/journal.pone.0009848.

4

Urine lipoarabinomannan assay for tuberculosis screening before antiretroviral therapy diagnostic yield and association with immune reconstitution disease.尿液脂阿拉伯甘露聚糖检测在抗逆转录病毒治疗前筛查结核病的诊断效果及其与免疫重建疾病的关系。

AIDS. 2009 Sep 10;23(14):1875-80. doi: 10.1097/qad.0b013e32832e05c8.

5

Diagnostic accuracy of commercial urinary lipoarabinomannan detection in African tuberculosis suspects and patients.商用尿中脂阿拉伯甘露聚糖检测对非洲结核病疑似患者及患者的诊断准确性

Int J Tuberc Lung Dis. 2009 Oct;13(10):1253-9.

6

Blinded evaluation of commercial urinary lipoarabinomannan for active tuberculosis: a pilot study.商业尿液脂阿拉伯甘露聚糖用于活动性肺结核的盲法评估：一项试点研究。

Int J Tuberc Lung Dis. 2009 Aug;13(8):989-95.

7

Low sensitivity of a urine LAM-ELISA in the diagnosis of pulmonary tuberculosis.尿液LAM-ELISA在肺结核诊断中的低敏感性。

BMC Infect Dis. 2009 Aug 28;9:141. doi: 10.1186/1471-2334-9-141.

8

Diagnostic accuracy of a urine lipoarabinomannan test for tuberculosis in hospitalized patients in a High HIV prevalence setting.在 HIV 高发环境中，住院患者尿液脂阿拉伯甘露聚糖检测对结核病的诊断准确性。

J Acquir Immune Defic Syndr. 2009 Oct 1;52(2):145-51. doi: 10.1097/QAI.0b013e3181b98430.

9

Approaches to tuberculosis screening and diagnosis in people with HIV in resource-limited settings.资源有限环境下HIV感染者结核病筛查与诊断方法

Lancet Infect Dis. 2009 Mar;9(3):173-84. doi: 10.1016/S1473-3099(09)70043-X.

10

HIV-associated tuberculosis: diagnostic and treatment challenges.人类免疫缺陷病毒相关结核病：诊断与治疗挑战

Semin Respir Crit Care Med. 2008 Oct;29(5):525-31. doi: 10.1055/s-0028-1085703. Epub 2008 Sep 22.

基于尿液的脂阿拉伯甘露聚糖检测在结核病患者中的定量分析。

Quantitative analysis of a urine-based assay for detection of lipoarabinomannan in patients with tuberculosis.

机构信息

Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

出版信息

J Clin Microbiol. 2010 Aug;48(8):2972-4. doi: 10.1128/JCM.00363-10. Epub 2010 Jun 9.

DOI:10.1128/JCM.00363-10

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2916614/

Abstract

Urinary lipoarabinomannan (LAM) detection is a promising approach for rapid diagnosis of active tuberculosis (TB). In microbiologically confirmed TB patients, quantitative LAM detection results increased progressively with bacillary burden and immunosuppression. Patients with disseminated TB and/or advanced HIV are target populations for whom urine LAM detection may be particularly useful.

摘要

尿脂阿拉伯甘露聚糖（LAM）检测是一种有前途的快速诊断活动性肺结核（TB）的方法。在微生物学确诊的 TB 患者中，定量 LAM 检测结果随细菌负担和免疫抑制的增加而逐渐增加。患有播散性 TB 和/或晚期 HIV 的患者是该检测方法特别有用的目标人群。