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同时使用低复杂度自动核酸扩增检测和侧向流动尿液脂阿拉伯甘露聚糖检测来检测感染艾滋病毒的成人和青少年中的结核病。

Parallel use of low-complexity automated nucleic acid amplification tests and lateral flow urine lipoarabinomannan assays to detect tuberculosis disease in adults and adolescents living with HIV.

作者信息

Bjerrum Stephanie, Yang Bada, Åhsberg Johanna, Nathavitharana Ruvandhi R, Olbrich Laura, Jaganath Devan, Kay Alexander W, Lundh Andreas, Shah Maunank

机构信息

Department of Clinical Research, Research Unit of Infectious Diseases, University of Southern Denmark, Odense, Denmark.

Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

出版信息

Cochrane Database Syst Rev. 2024 May 13;5(5):CD016070. doi: 10.1002/14651858.CD016070.

DOI:10.1002/14651858.CD016070
PMID:39908067
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11089515/
Abstract

This is a protocol for a Cochrane Review (diagnostic). The objectives are as follows: To compare the diagnostic accuracy of parallel use of lateral flow urine lipoarabinomannan on urine and low-complexity automated nucleic acid amplification tests on respiratory samples versus each test alone for detection of tuberculosis disease in adults and adolescents living with HIV who present with presumptive tuberculosis. Secondary objectives To investigate the following sources of heterogeneity: clinical setting; signs and symptoms of tuberculosis; screening positivity for tuberculosis disease by chest x-ray, C-reactive protein elevation, and molecular World Health Organization-recommended rapid diagnostics; seriously ill; advanced HIV; and CD4 cell count.

摘要

这是一项Cochrane系统评价（诊断性）的方案。目标如下：比较并行使用尿液侧流脂阿拉伯甘露聚糖检测和呼吸道样本低复杂度自动化核酸扩增检测与单独使用每项检测对疑似结核病的成人和青少年HIV感染者结核病的诊断准确性。次要目标：调查以下异质性来源：临床环境；结核病的体征和症状；通过胸部X光、C反应蛋白升高以及世界卫生组织推荐的分子快速诊断法进行结核病筛查呈阳性；重症；晚期HIV；以及CD4细胞计数。

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1
Parallel use of low-complexity automated nucleic acid amplification tests and lateral flow urine lipoarabinomannan assays to detect tuberculosis disease in adults and adolescents living with HIV.同时使用低复杂度自动核酸扩增检测和侧向流动尿液脂阿拉伯甘露聚糖检测来检测感染艾滋病毒的成人和青少年中的结核病。
Cochrane Database Syst Rev. 2024 May 13;5(5):CD016070. doi: 10.1002/14651858.CD016070.
2
Parallel use of low-complexity automated nucleic acid amplification tests and lateral flow urine lipoarabinomannan assays to detect tuberculosis disease in adults and adolescents living with HIV.并行使用低复杂度自动化核酸扩增检测和侧向流动尿液脂阿拉伯甘露聚糖检测，以检测感染艾滋病毒的成人和青少年中的结核病。
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Parallel use of low-complexity automated nucleic acid amplification tests on respiratory samples and stool with or without lateral flow lipoarabinomannan assays to detect pulmonary tuberculosis disease in children.在有或没有侧向流动脂阿拉伯甘露聚糖检测的情况下，对呼吸道样本和粪便同时使用低复杂度自动核酸扩增检测来检测儿童肺结核病。
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Parallel use of low-complexity automated nucleic acid amplification tests on respiratory and stool samples with or without lateral flow lipoarabinomannan assays to detect pulmonary tuberculosis disease in children.在有或没有侧向流动脂阿拉伯甘露聚糖检测的情况下，对呼吸道和粪便样本并行使用低复杂度自动核酸扩增检测以检测儿童肺结核病。
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引用本文的文献

1
Parallel use of low-complexity automated nucleic acid amplification tests on respiratory and stool samples with or without lateral flow lipoarabinomannan assays to detect pulmonary tuberculosis disease in children.在有或没有侧向流动脂阿拉伯甘露聚糖检测的情况下，对呼吸道和粪便样本并行使用低复杂度自动核酸扩增检测以检测儿童肺结核病。
Cochrane Database Syst Rev. 2025 Jun 11;6(6):CD016071. doi: 10.1002/14651858.CD016071.pub2.
2
Parallel use of low-complexity automated nucleic acid amplification tests and lateral flow urine lipoarabinomannan assays to detect tuberculosis disease in adults and adolescents living with HIV.并行使用低复杂度自动化核酸扩增检测和侧向流动尿液脂阿拉伯甘露聚糖检测，以检测感染艾滋病毒的成人和青少年中的结核病。
Cochrane Database Syst Rev. 2025 Jun 10;6(6):CD016070. doi: 10.1002/14651858.CD016070.pub2.

本文引用的文献

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Prospective multicentre accuracy evaluation of the FUJIFILM SILVAMP TB LAM test for the diagnosis of tuberculosis in people living with HIV demonstrates lot-to-lot variability.前瞻性多中心评估富士胶片 SILVAMP TB LAM 检测试验对 HIV 感染者结核病诊断的准确性，结果显示不同批次间存在变异性。
PLoS One. 2024 May 31;19(5):e0303846. doi: 10.1371/journal.pone.0303846. eCollection 2024.
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Evaluating medical tests: introducing the Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy.评估医学检验：介绍《Cochrane诊断试验准确性系统评价手册》
Cochrane Database Syst Rev. 2023 Jul 20;7(7):ED000163. doi: 10.1002/14651858.ED000163.
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Diagnostic yield of urine lipoarabinomannan and sputum tuberculosis tests in people living with HIV: a systematic review and meta-analysis of individual participant data.对 HIV 感染者进行尿液脂阿拉伯甘露聚糖检测和痰结核分枝杆菌检测的诊断效果：一项个体参与者数据的系统评价和荟萃分析。
Lancet Glob Health. 2023 Jun;11(6):e903-e916. doi: 10.1016/S2214-109X(23)00135-3.
4
Novel FujiLAM assay to detect tuberculosis in HIV-positive ambulatory patients in four African countries: a diagnostic accuracy study.新型 FujiLAM 检测法在四个非洲国家的 HIV 阳性门诊患者中检测结核病的诊断准确性研究。
Lancet Glob Health. 2023 Jan;11(1):e126-e135. doi: 10.1016/S2214-109X(22)00463-6.
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Tuberculosis screening among HIV-positive inpatients: a systematic review and individual participant data meta-analysis.HIV 阳性住院患者的结核病筛查：系统评价和个体参与者数据荟萃分析。
Lancet HIV. 2022 Apr;9(4):e233-e241. doi: 10.1016/S2352-3018(22)00002-9. Epub 2022 Mar 23.
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Tuberculosis screening among ambulatory people living with HIV: a systematic review and individual participant data meta-analysis.HIV 感染者门诊人群中的结核病筛查：系统评价和个体参与者数据荟萃分析。
Lancet Infect Dis. 2022 Apr;22(4):507-518. doi: 10.1016/S1473-3099(21)00387-X. Epub 2021 Nov 17.
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Ann Intern Med. 2021 Nov;174(11):1592-1599. doi: 10.7326/M21-2234. Epub 2021 Oct 26.
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Eur Respir J. 2021 Nov 4;58(5). doi: 10.1183/13993003.00526-2021. Print 2021 Oct.
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