Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Am J Epidemiol. 2010 Jul 15;172(2):205-16. doi: 10.1093/aje/kwq089. Epub 2010 Jun 9.
Antioxidants may protect against development of rheumatoid arthritis or systemic lupus erythematosus by combating oxidative stress. The authors identified and confirmed incident cases of rheumatoid arthritis and systemic lupus erythematosus among 184,643 US women followed in the Nurses' Health Study and Nurses' Health Study II cohorts in 1980-2004. Semiquantitative food frequency questionnaires assessed intakes of vitamins A, C, and E and alpha-carotene, beta-carotene, beta-cryptoxanthin, lycopene, lutein, and zeaxanthin from foods and supplements. The authors examined total antioxidant intake by calculating a "ferric-reducing ability of plasma" score, a new method for quantifying the total antioxidant effect of a food based on the reduction of ferric to ferrous iron by antioxidants. Cumulative updated total energy-adjusted dietary intakes were used. Associations between intake of each nutrient and incident rheumatoid arthritis and systemic lupus erythematosus were examined in age-adjusted and Cox proportional hazards models, adjusted for confounders. Results from the cohorts were pooled meta-analytically by using random-effects models. The authors identified 787 incident rheumatoid arthritis cases and 192 systemic lupus erythematosus cases for whom prospective dietary information was available. In these large, prospective cohorts of women, antioxidant intake was not associated with the risk of developing either rheumatoid arthritis or systemic lupus erythematosus.
抗氧化剂通过抵抗氧化应激可能对类风湿关节炎或系统性红斑狼疮的发展起到预防作用。作者通过对 1980-2004 年间参与护士健康研究和护士健康研究 II 队列的 184643 名美国女性进行随访，发现并确认了类风湿关节炎和系统性红斑狼疮的新发病例。半定量食物频率问卷评估了从食物和补充剂中摄取的维生素 A、C 和 E 以及α-胡萝卜素、β-胡萝卜素、β-隐黄质、番茄红素、叶黄素和玉米黄质。作者通过计算“血浆铁还原能力”评分来评估总抗氧化剂的摄入量，这是一种基于抗氧化剂还原铁离子为亚铁离子来量化食物总抗氧化效果的新方法。使用累积更新的总能量调整后的膳食摄入量进行分析。在年龄调整和 Cox 比例风险模型中，对每种营养素与类风湿关节炎和系统性红斑狼疮发病风险之间的关系进行了分析，并对混杂因素进行了调整。使用随机效应模型对队列结果进行了荟萃分析。作者确定了 787 例新发病例的类风湿关节炎和 192 例系统性红斑狼疮，这些患者可提供前瞻性饮食信息。在这些针对女性的大型前瞻性队列中，抗氧化剂的摄入量与发生类风湿关节炎或系统性红斑狼疮的风险无关。
