Pattison Dorothy J, Symmons Deborah P M, Lunt Mark, Welch Ailsa, Bingham Sheila A, Day Nicholas E, Silman Alan J
Arthritis Research Campaign Epidemiology Unit, The University of Manchester, Manchester, United Kingdom.
Am J Clin Nutr. 2005 Aug;82(2):451-5. doi: 10.1093/ajcn.82.2.451.
Epidemiologic studies suggest that the antioxidant potential of dietary carotenoids may protect against the oxidative damage that can result in inflammation.
We investigated the hypothesis that some dietary carotenoids are associated with a reduced risk of developing inflammatory polyarthritis (IP).
The European Prospective Investigation of Cancer Incidence (EPIC)-Norfolk study is a population-based, prospective study of >25,000 subjects who completed a baseline 7-d diet diary and were followed up to identify new cases of IP, which was defined as synovitis that affected > or = 2 joint groups. Dietary carotenoid intakes were computed from the diet diaries of these subjects, and a nested, case-control analysis was undertaken to compare carotenoid intake between case subjects and age- and sex-matched control subjects.
Eighty-eight incident cases of IP that occurred in the population surveyed were ascertained via the Norfolk Arthritis Register. The mean daily intakes of zeaxanthin and beta-cryptoxanthin were 20% and 40% lower, respectively, in the cases than in the 176 controls, but there were no significant differences in the intakes of either lutein or lycopene. Those subjects in the top one-third of intake of zeaxanthin and beta-cryptoxanthin were at a lower risk of developing IP than were subjects in the lowest one-third [odds ratios (95% CI): 0.48 (0.24, 0.94) and 0.51 (0.25, 1.02) for zeaxanthin and beta-cryptoxanthin, respectively]. The association with beta-cryptoxanthin was significant after adjustments were made for total energy and protein intakes and for cigarette smoking.
These data are consistent with previous evidence showing that a modest increase in beta-cryptoxanthin intake, equivalent to one glass of freshly squeezed orange juice per day, is associated with a reduced risk of developing inflammatory disorders such as rheumatoid arthritis.
流行病学研究表明，膳食类胡萝卜素的抗氧化潜力可能有助于抵御可导致炎症的氧化损伤。
我们对以下假设进行了研究，即某些膳食类胡萝卜素与炎性多关节炎（IP）发病风险降低有关。
欧洲癌症发病率前瞻性调查（EPIC）-诺福克研究是一项基于人群的前瞻性研究，研究对象超过25000名，他们完成了一份为期7天的基线饮食日记，并接受随访以确定IP新病例，IP定义为影响≥2个关节组的滑膜炎。根据这些研究对象的饮食日记计算膳食类胡萝卜素摄入量，并进行巢式病例对照分析，以比较病例组与年龄和性别匹配的对照组之间的类胡萝卜素摄入量。
通过诺福克关节炎登记处确定了在调查人群中发生的88例IP新发病例。病例组中玉米黄质和β-隐黄质的平均每日摄入量分别比176名对照组低20%和40%，但叶黄素或番茄红素的摄入量没有显著差异。玉米黄质和β-隐黄质摄入量处于最高三分之一的研究对象发生IP的风险低于摄入量最低三分之一的研究对象[玉米黄质和β-隐黄质的优势比（95%CI）分别为0.48（0.24，0.94）和0.51（0.25，1.02）]。在对总能量、蛋白质摄入量和吸烟情况进行调整后，与β-隐黄质的关联具有统计学意义。
这些数据与之前的证据一致，表明β-隐黄质摄入量适度增加（相当于每天一杯鲜榨橙汁）与类风湿关节炎等炎性疾病发病风险降低有关。
