微小 RNA 在心脏缺血性损伤中的表达和功能。
MicroRNA expression and function in cardiac ischemic injury.
机构信息
Department of Neurosurgery, LSU Health Science Center, Shreveport, LA 71130, USA.
出版信息
J Cardiovasc Transl Res. 2010 Jun;3(3):241-5. doi: 10.1007/s12265-010-9168-8.
Abstract
Ischemic heart disease (IHD) or myocardial ischemia is one of the leading causes of mortality all over the world. There is a definite need for new approaches to improve therapies and diagnostics. The pathological process leading to IHD is associated with an altered expression of genes that are important for cardiac functions. Micro-RNAs (miRNAs) have emerged as one of the central players regulating gene expression via degradation or translational inhibition of their target genes. Increasing evidence indicates that miRNAs may serve as potential diagnostic biomarkers and innovative therapeutic targets in several human diseases including cardiovascular disease. Here, we review the latest advances in the identification and validation of myocardial ischemia-related miRNAs and their target genes and discuss the roles of specific miRNAs in regulating ischemia-related cardiac injury, including apoptosis, fibrosis, arrhythmia, and angiogenesis.
摘要
缺血性心脏病（IHD）或心肌缺血是全球死亡的主要原因之一。确实需要新的方法来改善治疗和诊断。导致 IHD 的病理过程与对心脏功能重要的基因表达的改变有关。Micro-RNAs（miRNAs）已成为通过降解或翻译抑制其靶基因来调节基因表达的核心参与者之一。越来越多的证据表明，miRNAs 可能作为几种人类疾病（包括心血管疾病）的潜在诊断生物标志物和创新治疗靶点。在这里，我们回顾了鉴定和验证与心肌缺血相关的 miRNAs 及其靶基因的最新进展，并讨论了特定 miRNAs 在调节与缺血相关的心脏损伤中的作用，包括细胞凋亡、纤维化、心律失常和血管生成。
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