Departamento de Pediatria, Faculdade de Medicina de Jundiaí, São Paulo, Brazil.
Clinics (Sao Paulo). 2010 May;65(5):548-54. doi: 10.1590/S1807-59322010000500013.
Data collected from medical literature indicate that dopaminergic agonists alleviate Restless Legs Syndrome symptoms while dopaminergic agonists antagonists aggravate them. Dopaminergic agonists is a physiological regulator of thyroid-stimulating hormone. Dopaminergic agonists infusion diminishes the levels of thyroid hormones, which have the ability to provoke restlessness, hyperkinetic states, tremors, and insomnia. Conditions associated with higher levels of thyroid hormones, such as pregnancy or hyperthyroidism, have a higher prevalence of Restless Legs Syndrome symptoms. Low iron levels can cause secondary Restless Legs Syndrome or aggravate symptoms of primary disease as well as diminish enzymatic activities that are involved in dopaminergic agonists production and the degradation of thyroid hormones. Moreover, as a result of low iron levels, dopaminergic agonists diminishes and thyroid hormones increase. Iron therapy improves Restless Legs Syndrome symptoms in iron deprived patients. Medical hypothesis. To discuss the theory that thyroid hormones, when not counterbalanced by dopaminergic agonists, may precipitate the signs and symptoms underpinning Restless Legs Syndrome. The main cause of Restless Legs Syndrome might be an imbalance between the dopaminergic agonists system and thyroid hormones.
从医学文献中收集的数据表明，多巴胺激动剂可缓解不安腿综合征的症状，而多巴胺激动剂拮抗剂则会加重这些症状。多巴胺激动剂是甲状腺刺激激素的生理调节剂。多巴胺激动剂输注会降低甲状腺激素水平，而甲状腺激素会引起不安、多动状态、震颤和失眠。与甲状腺激素水平较高相关的疾病，如妊娠或甲状腺功能亢进症，不安腿综合征的症状更为普遍。铁水平低会导致继发性不安腿综合征或加重原发性疾病的症状，同时还会降低涉及多巴胺激动剂产生和甲状腺激素降解的酶活性。此外，由于铁水平低，多巴胺激动剂减少，而甲状腺激素增加。铁疗法可改善缺铁患者的不安腿综合征症状。医学假说。讨论甲状腺激素在没有多巴胺激动剂平衡的情况下可能引发不安腿综合征基础症状和体征的理论。不安腿综合征的主要原因可能是多巴胺激动剂系统和甲状腺激素之间的失衡。
