Tan Eng-King, Ho Su-Chin, Koh Leonard, Pavanni Ratnagopal
Department of Neurology, Singapore General Hospital, Singapore.
Mov Disord. 2004 Nov;19(11):1365-7. doi: 10.1002/mds.20219.
We report on the cause and effect relationship of restless legs syndrome (RLS) with L-thyroxine treatment in a hypothyroid patient with low serum ferritin. Upon challenge and withdrawal of L-thyroxine, there was a significant change in the International Restless Legs Syndrome Study Group severity score (26/40 to 6/40), the periodic limb movements (PMLS) index (20/hour to 10/hour), the number of arousals due to PLMS (59 to 22), sleep efficiency (74 to 85%), and biochemical parameters. RLS symptoms can complicate thyroxine replacement in at-risk hypothyroid patients with low serum ferritin. Early diagnosis and iron replacement could significantly reduce patient morbidity.
我们报告了一名血清铁蛋白水平低的甲状腺功能减退患者中，不安腿综合征（RLS）与左甲状腺素治疗之间的因果关系。在给予和停用左甲状腺素时，国际不安腿综合征研究组严重程度评分（从26/40降至6/40）、周期性肢体运动（PMLS）指数（从20次/小时降至10次/小时）、因周期性肢体运动相关睡眠觉醒次数（从59次降至22次）、睡眠效率（从74%升至85%）及生化参数均有显著变化。对于血清铁蛋白水平低的高危甲状腺功能减退患者，RLS症状会使甲状腺素替代治疗复杂化。早期诊断和补充铁剂可显著降低患者发病率。
