Orthopedic Department, General Hospital of Tianjin Medical University, Number 154, An Shan Road, Heping district, Tianjin, 300052, China.
Clin Rheumatol. 2010 Sep;29(9):983-90. doi: 10.1007/s10067-010-1499-y. Epub 2010 Jun 11.
The relationship of TNF-alpha promoter polymorphisms and ankylosing spondylitis (AS) has been reported with conflicting results. We perform this meta-analysis to collect all the relevant studies up to date to further clarify the association of TNF-alpha promoter polymorphisms with AS. A review was conducted of studies reporting on the association between TNF-alpha promoter polymorphisms and AS susceptibility in Medline, Pubmed, Embase, and Web of Science. The numbers of individuals with various genotypes and alleles in both the case and control groups were extracted from relevant studies. Odds ratios (ORs) with 95% confidence interval (CI) were used to estimate the association. Fourteen eligible studies, contributing data on 3,880 subjects (1,766 patients; 2,114 controls), were included in this meta-analysis. The ORs of various comparisons indicated that there was no association between TNF-alpha 238, 308 polymorphisms, and AS susceptibility in the overall population. For HLA-B27+ population, although the frequency of 308 A allele decreased in AS patients (OR = 0.721; 95%CI = 0.522-0.995), the result was no longer statistically significant after excluding the Hardy-Weinberg equilibrium violation studies (OR = 1.150; 95%CI = 0.568-2.310). No relationship was found between TNF-alpha promoter 238 polymorphisms and AS in HLA-b27+ population. No association was found between TNF-alpha promoter 238/308 polymorphisms and ankylosing spondylitis susceptibility in both the overall and HLA-B27+ population.
TNF-α 启动子多态性与强直性脊柱炎（AS）的关系已有报道，但结果相互矛盾。我们进行这项荟萃分析，收集迄今为止所有相关研究，以进一步阐明 TNF-α 启动子多态性与 AS 的相关性。我们检索了 Medline、Pubmed、Embase 和 Web of Science 中关于 TNF-α 启动子多态性与 AS 易感性相关的研究。从相关研究中提取病例组和对照组中各种基因型和等位基因的个体数量。使用比值比（OR）及其 95%置信区间（CI）来估计相关性。本荟萃分析纳入了 14 项符合条件的研究，共涉及 3880 名受试者（1766 名患者；2114 名对照）。各种比较的 OR 表明，TNF-α 238、308 多态性与总体人群 AS 易感性之间无关联。对于 HLA-B27+ 人群，虽然 AS 患者中 308 A 等位基因的频率降低（OR = 0.721；95%CI = 0.522-0.995），但排除 Hardy-Weinberg 平衡破坏研究后，结果不再具有统计学意义（OR = 1.150；95%CI = 0.568-2.310）。TNF-α 启动子 238 多态性与 HLA-b27+ 人群中的 AS 之间没有关系。在 HLA-B27+人群中，TNF-α 启动子 238/308 多态性与强直性脊柱炎易感性之间也没有关联。
