Department of Rheumatology and Immunology, Shandong Provincial Hospital, Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.
Department of Rheumatology and Immunology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250021, Shandong, China.
Eur Spine J. 2021 Aug;30(8):2401-2408. doi: 10.1007/s00586-021-06892-3. Epub 2021 Jun 8.
Human leukocyte antigen (HLA)-B27 plays a crucial role in the pathogenesis of AS. TNF polymorphisms have been reported to be associated with AS susceptibility, but the results of these previous studies have been inconsistent. The aim of this study was to explore whether TNF polymorphism is associated with AS susceptibility in HLA-27-positive population.
Our search was done in the Pubmed, Embase, and Cochrane databases (up to March 2020). The pooled and individual odds ratios (ORs) with 95% confidence intervals (CIs) of the minor allele of each locus were presented to assess the associations between TNF polymorphisms and AS in HLA-B27-positive population.
Ten studies from 8 articles were included in this meta-analysis. In the population of HLA-B27-positive patients and random healthy controls, there were statistical significance in the evaluation of association between the minor allele of TNF-238, -308, -857, -1031 and -863 and AS susceptibility, respectively. In the population of HLA-B27-positive patients and HLA-B27-positive healthy controls, there were no statistical differences in the comparison of minor allele of with their respective major allele in the fixed model.
There was no association of the TNF polymorphisms with AS in the HLA-B27-positive AS group and HLA-B27-positive control group. Polymorphisms of TNF-238, -308, -857, -1031, -863 were associated with AS susceptibility in the HLA-B27-positive AS patients and random control population. Other gene SNPs except TNF may play an important role in AS susceptibility in HLA-B27-positive population.
人类白细胞抗原（HLA）-B27 在 AS 的发病机制中起关键作用。据报道，TNF 多态性与 AS 易感性相关，但这些先前研究的结果并不一致。本研究旨在探讨 TNF 多态性是否与 HLA-B27 阳性人群的 AS 易感性相关。
我们在 Pubmed、Embase 和 Cochrane 数据库中进行了搜索（截至 2020 年 3 月）。使用合并和个体优势比（OR）及其 95%置信区间（CI）来评估每个位点的次要等位基因与 HLA-B27 阳性人群中 TNF 多态性与 AS 之间的关联。
本荟萃分析纳入了 8 篇文章中的 10 项研究。在 HLA-B27 阳性患者和随机健康对照人群中，TNF-238、-308、-857、-1031 和-863 的次要等位基因与 AS 易感性之间存在统计学意义。在 HLA-B27 阳性患者和 HLA-B27 阳性健康对照人群中，在固定模型中比较其各自主要等位基因时，TNF 多态性与 AS 之间没有统计学差异。
在 HLA-B27 阳性 AS 组和 HLA-B27 阳性对照组中，TNF 多态性与 AS 无相关性。TNF-238、-308、-857、-1031、-863 多态性与 HLA-B27 阳性 AS 患者和随机对照人群的 AS 易感性相关。除 TNF 外，其他基因 SNPs 可能在 HLA-B27 阳性人群的 AS 易感性中起重要作用。
