Departamento de Química Láser. Instituto de Química Física Rocasolano, Consejo Superior de Investigaciones Científicas, CSiC C/ Serrano 119, 2806, Madrid, Spain.
Lasers Med Sci. 2011 Jul;26(4):453-63. doi: 10.1007/s10103-010-0795-8. Epub 2010 Jun 10.
In recent years, the use of laser radiation has been investigated as an alternative or adjunctive tool to conventional procedures employed in the treatment of periodontal disease. Various beneficial characteristics of Nd:YAG laser radiation, such as hemostatic and bactericidal effects, might lead to improved treatment outcomes. The objective of the present study was to examine the clinical, microbiological, and anti-inflammatory efficacy of Nd:YAG laser periodontal pocket irradiation as an adjunct to scaling and root planing (SRP). Thirty patients with chronic periodontitis (CP) were randomly assigned in parallel groups to receive SRP alone or SRP followed by Nd:YAG laser (λ = 1,064 nm) (SRP+NDL). Probing pocket depth (PPD), bleeding on probing (BOP), and plaque index (PI) were recorded, and samples of gingival crevicular fluid (GCF) and subgingival microbiota were taken at baseline and post-therapy (4 and 8 weeks after treatment). The laser therapy was performed 1 day after the SRP procedure. The GCF samples were analyzed for interleukin-1beta (IL-1β), tumor necrosis factor alpha (TNF-α), and total antioxidative status (TAS). Microbiological samples were cultured and analyzed for ten bacteria. No statistically significant differences were detected for clinical or microbiological variables between SRP and SRP+NDL treatments. However, levels of IL-1 β in GCF were significantly lower after SRP+NDL treatment when compared to IL-1 β levels obtained by SRP alone after 4 weeks of treatment. Levels of TNF-α were significantly lower after the SRP+NDL treatment during post-therapy. TAS of GCF increased during post-therapy after the SRP+NDL treatment. However, after SRP alone, it remained constant. In this short-term clinical study Nd:YAG laser radiation in the treatment of CP is showed to be a potential adjunct to conventional SRP.
近年来，激光辐射已被研究作为牙周病治疗中传统方法的替代或辅助手段。Nd:YAG 激光辐射的各种有益特性，如止血和杀菌作用，可能会导致治疗效果的改善。本研究的目的是检查 Nd:YAG 激光牙周袋照射作为龈下刮治和根面平整（SRP）辅助治疗的临床、微生物学和抗炎疗效。将 30 名慢性牙周炎（CP）患者随机分为平行组，分别接受单独 SRP 或 SRP 后接受 Nd:YAG 激光（λ=1,064nm）（SRP+NDL）治疗。记录探诊袋深度（PPD）、探诊出血（BOP）和菌斑指数（PI），并在基线和治疗后（治疗后 4 周和 8 周）采集龈沟液（GCF）和龈下微生物样本。激光治疗在 SRP 后 1 天进行。分析 GCF 样本中的白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）和总抗氧化状态（TAS）。对微生物样本进行培养和分析 10 种细菌。SRP 和 SRP+NDL 治疗之间的临床或微生物学变量无统计学差异。然而，与单独 SRP 治疗后 4 周获得的 IL-1β水平相比，SRP+NDL 治疗后 GCF 中 IL-1β水平显著降低。治疗后，SRP+NDL 治疗后 TNF-α水平显著降低。SRP+NDL 治疗后 GCF 的 TAS 在治疗后增加。然而，单独 SRP 后，它保持不变。在这项短期临床研究中，Nd:YAG 激光辐射治疗 CP 显示出作为传统 SRP 的潜在辅助手段的潜力。
