Cheng Y, Chen J W, Ge M K, Zhou Z Y, Yin X, Zou S J
State Key Laboratory of Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, 14, Section 3, Ren Min Nan Road, 610041, Chengdu, China.
Lasers Med Sci. 2016 Jan;31(1):151-63. doi: 10.1007/s10103-015-1795-5. Epub 2015 Sep 2.
To evaluate the efficacy of the adjunctive laser therapy in conventional non-surgical treatment of chronic periodontitis, an electronic search was performed through the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, MEDLINE, EMBASE, Scopus, Web of Science, China National Knowledge Infrastructure (CNKI), and China Biology Medicine (CBM) Disc, for relevant randomized controlled trials (RCTs) or quasi-RCTs. All the 12 included studies (11 RCTs and 1 quasi-RCT) were qualified for descriptive and quantitative analysis. Outcomes were divided into two groups according to the length of follow-ups (long term and short term). Subgroup analyses were performed based on the mode of laser (inside and outside mode). Among all included researches, reduction in probing depth (PD) and gain in clinical attachment level (CAL) were presented with the mean value and 95 % confidence interval, while bleeding on probing (BOP) was assessed descriptively. Meta-analysis suggested that adjunctive laser therapy reduced PD at 3 months [mean difference (MD) = -0.26, 95 % confidence interval (CI) range = -0.43 to -0.09, p = 0.003] but did not demonstrate significant effect on the CAL at either 3 months (MD = -0.03, 95 % CI range = -0.25 to 0.19, p = 0.79) or 6 months (MD = -0.11, 95 % CI range = -0.38 to 0.16, p = 0.43). Subgroup analyses indicated that laser therapy would be more effective when the probes were set up outside the periodontal pockets.
为评估辅助激光治疗在慢性牙周炎传统非手术治疗中的疗效，我们通过Cochrane对照试验中心注册库（CENTRAL）、PubMed、MEDLINE、EMBASE、Scopus、Web of Science、中国知网（CNKI）和中国生物医学文献数据库（CBM Disc）进行了电子检索，以查找相关的随机对照试验（RCT）或半随机对照试验（quasi-RCT）。所有纳入的12项研究（11项RCT和1项quasi-RCT）均符合描述性和定量分析的要求。根据随访时间长短（长期和短期）将结果分为两组。基于激光模式（袋内和袋外模式）进行亚组分析。在所有纳入的研究中，探诊深度（PD）的降低和临床附着水平（CAL）的增加以平均值和95%置信区间表示，而探诊出血（BOP）则进行描述性评估。荟萃分析表明，辅助激光治疗在3个月时可降低PD[平均差（MD）=-0.26，95%置信区间（CI）范围=-0.43至-0.09，p=0.003]，但在3个月（MD=-0.03，95%CI范围=-0.25至0.19，p=0.79）或6个月（MD=-0.11，95%CI范围=-0.38至0.16，p=0.43）时对CAL均未显示出显著效果。亚组分析表明，当探头置于牙周袋外时，激光治疗效果更佳。
