Lime Trees Child, Adolescent and Family Unit, 31 Shipton Road, York, North Yorkshire, YO30 5RE, England, UK.
J Autism Dev Disord. 2011 Feb;41(2):175-84. doi: 10.1007/s10803-010-1036-5.
Twenty-two children with autism spectrum disorders who had not responded to supported behaviour management strategies for severe dysomnias entered a double blind, randomised, controlled crossover trial involving 3 months of placebo versus 3 months of melatonin to a maximum dose of 10 mg. 17 children completed the study. There were no significant differences between sleep variables at baseline. Melatonin significantly improved sleep latency (by an average of 47 min) and total sleep (by an average of 52 min) compared to placebo, but not number of night wakenings. The side effect profile was low and not significantly different between the two arms.
22 名自闭症谱系障碍儿童对支持行为管理策略治疗严重睡眠障碍没有反应，他们参与了一项双盲、随机、对照交叉试验，接受为期 3 个月的安慰剂对照和 3 个月的褪黑素（最大剂量 10mg）治疗。17 名儿童完成了这项研究。在基线时，睡眠变量没有显著差异。与安慰剂相比，褪黑素显著改善了睡眠潜伏期（平均 47 分钟）和总睡眠时间（平均 52 分钟），但对夜间觉醒次数没有影响。副作用谱较低，两组之间无显著差异。
