激素对认知功能和阿尔茨海默病风险的影响。
Hormonal influences on cognition and risk for Alzheimer's disease.
机构信息
G. H. Sergievsky Center, Columbia University Medical Center, 622 West 168th Street, PH-19, New York, NY 10019, USA.
出版信息
Curr Neurol Neurosci Rep. 2010 Sep;10(5):359-66. doi: 10.1007/s11910-010-0122-6.
Abstract
Research increasingly suggests that changes in estrogen levels during aging may increase the risk of Alzheimer's disease, the most common type of dementia. This update reviews the newest information about estrogen and cognitive aging, including information regarding the role of bioavailable estrogen in older women and men, use of selective estrogen receptor modulators to improve cognition, and studies of genetic risk factors to elucidate the effects of endogenous estrogen on aging and cognition. Future trials are needed to determine whether alternate timing, dosage, formulation, or method of administration of hormone replacement can reduce the risk of dementia.
摘要
研究越来越表明，衰老过程中雌激素水平的变化可能会增加阿尔茨海默病的风险，这是最常见的痴呆症类型。本综述回顾了最新的关于雌激素和认知衰老的信息，包括关于生物可利用雌激素在老年女性和男性中的作用、使用选择性雌激素受体调节剂改善认知的信息，以及研究遗传风险因素以阐明内源性雌激素对衰老和认知的影响。需要进一步的临床试验来确定激素替代疗法的替代时间、剂量、配方或给药方式是否可以降低痴呆症的风险。
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