Li Rena, Cui Jie, Shen Yong
Center for Hormone Advanced Science and Education (CHASE), Roskamp Institute, Sarasota, FL 34243, United States.
Center for Hormone Advanced Science and Education (CHASE), Roskamp Institute, Sarasota, FL 34243, United States.
Mol Cell Endocrinol. 2014 May 25;389(1-2):13-21. doi: 10.1016/j.mce.2013.12.018. Epub 2014 Jan 11.
Estrogens are the primary female sex hormones and play important roles in both reproductive and non-reproductive systems. Estrogens can be synthesized in non-reproductive tissues such as liver, heart, muscle, bone and the brain. During the past decade, increasing evidence suggests that brain estrogen can not only be synthesized by neurons, but also by astrocytes. Brain estrogen also works locally at the site of synthesis in paracrine and/or intracrine fashion to maintain important tissue-specific functions. Here, we will focus on the biology of brain estrogen and its impact on cognitive function and Alzheimer's disease. This comprehensive review provides new insights into brain estrogens by presenting a better understanding of the tissue-specific estrogen effects and their roles in healthy ageing and cognitive function.
雌激素是主要的女性性激素，在生殖系统和非生殖系统中均发挥着重要作用。雌激素可在肝脏、心脏、肌肉、骨骼和大脑等非生殖组织中合成。在过去十年中，越来越多的证据表明，脑内雌激素不仅可由神经元合成，还可由星形胶质细胞合成。脑内雌激素还以旁分泌和/或自分泌方式在合成部位局部发挥作用，以维持重要的组织特异性功能。在此，我们将聚焦于脑内雌激素的生物学特性及其对认知功能和阿尔茨海默病的影响。这篇全面的综述通过更深入地了解组织特异性雌激素效应及其在健康衰老和认知功能中的作用，为脑内雌激素提供了新的见解。
