Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, Oxford, UK.
Magn Reson Med. 2010 Sep;64(3):698-706. doi: 10.1002/mrm.22458.
A new noninvasive MRI method for vessel selective angiography is presented. The technique combines vessel-encoded pseudocontinuous arterial spin labeling with a two-dimensional dynamic angiographic readout and was used to image the cerebral arteries in healthy volunteers. Time-of-flight angiograms were also acquired prior to vessel-selective dynamic angiography acquisitions in axial, coronal, and/or sagittal planes, using a 3-T MRI scanner. The latter consisted of a vessel-encoded pseudocontinuous arterial spin labeling pulse train of 300 or 1000 ms followed by a two-dimensional thick-slab flow-compensated fast low angle shot readout combined with a segmented Look-Locker sampling strategy (temporal resolution = 55 ms). Selective labeling was performed at the level of the neck to generate individual angiograms for both right and left internal carotid and vertebral arteries. Individual vessel angiograms were reconstructed using a bayesian inference method. The vessel-selective dynamic angiograms obtained were consistent with the time-of-flight images, and the longer of the two vessel-encoded pseudocontinuous arterial spin labeling pulse train durations tested (1000 ms) was found to give better distal vessel visibility. This technique provides highly selective angiograms quickly and noninvasively that could potentially be used in place of intra-arterial x-ray angiography for larger vessels.
一种新的用于血管选择性血管造影的非侵入性 MRI 方法。该技术结合了血管编码伪连续动脉自旋标记与二维动态血管造影读出，并用于对健康志愿者的脑动脉进行成像。在进行血管选择性动态血管造影采集之前，还使用 3-T MRI 扫描仪在轴向、冠状和/或矢状平面上获取了时飞越血管造影。后者由 300 或 1000 ms 的血管编码伪连续动脉自旋标记脉冲串组成，随后是二维厚片流动补偿快速低角度 shot 读出，结合分段 Look-Locker 采样策略（时间分辨率 = 55 ms）。在颈部水平进行选择性标记，以生成右侧和左侧颈内动脉和椎动脉的个体血管造影。使用贝叶斯推断方法重建个体血管造影。获得的血管选择性动态血管造影与时飞越图像一致，并且测试的两种血管编码伪连续动脉自旋标记脉冲串持续时间较长（1000 ms），发现其能更好地显示远端血管。该技术快速提供高度选择性的血管造影，可能替代较大血管的动脉内 X 射线血管造影。
