Zhang Yan, Guo Ling-li, Zhao Shi-peng
Colorectal Surgical Department, the Third Hospital of Hebei Medical University, Shijiazhuang 050051.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010 Mar;30(3):280-2.
To explore the effect and mechanism of Shenqi Fuzheng Injection (SFI) for assisting of chemotherapy in treating colorectal cancer (CRC).
Forty CRC patients were randomly and equally assigned to two groups, the control group received chemotherapy of FOLFOX protocol and the test group treated with the same chemotherapy combining with SFI. The CD4+ CD25+ regulatory T (Treg) cells, tumor necrosis factor-alpha (TNF-alpha) and interleukin-12 (IL-12) in peripheral blood were determined before and after treatment, and the toxicity of chemotherapy assessed according to the WHO criteria for acute and subacute toxic reaction of anticancer drugs.
Two cases in the control group were lost during the observing period. The amount of CD4+ CD25+ Treg cells in peripheral blood in CRC patients was significantly higher than the normal range (P<0.05), which was lowered significantly after treatment in both groups (P<0.05). Levels of TNF-alpha and IL-12 significantly elevated in the test group after treatment but lowered in the control group, showing significant difference between groups (both P<0.05). As compared with the control group, the adverse reaction to the chemotherapy was significantly lessened in the test group (P<0.05).
Using SFI for assisting chemotherapy could not only improve the immune function of organism to enhance the effect of chemotherapy, but also reduce the adverse reaction of the chemotherapy.
探讨参芪扶正注射液（SFI）辅助化疗治疗结直肠癌（CRC）的效果及机制。
40例CRC患者随机等分为两组，对照组接受FOLFOX方案化疗，试验组在相同化疗基础上加用SFI。测定治疗前后外周血CD4+CD25+调节性T（Treg）细胞、肿瘤坏死因子-α（TNF-α）和白细胞介素-12（IL-12）水平，并根据世界卫生组织抗癌药物急性和亚急性毒性反应标准评估化疗毒性。
对照组在观察期间失访2例。CRC患者外周血CD4+CD25+Treg细胞数量显著高于正常范围（P<0.05），两组治疗后均显著降低（P<0.05）。试验组治疗后TNF-α和IL-12水平显著升高，而对照组降低，两组间差异有统计学意义（均P<0.05）。与对照组相比，试验组化疗不良反应明显减轻（P<0.05）。
SFI辅助化疗不仅可提高机体免疫功能以增强化疗效果，还可降低化疗不良反应。
