Hayashida Tetsu, Jinno Hiromitsu, Sakata Michio, Takahashi Maiko, Kitagawa Yuko
Department of Surgery, School of Medicine, Keio University.
Nihon Rinsho. 2010 Jun;68(6):1137-42.
Active clinical researches for breast cancer advance the therapeutic strategies remarkably, however, it seems to be more difficult to choose the appropriate treatment based on the evidence for each patient due to its diversification. Moreover, the striking achievements of various molecular targeting drugs established by basic researches make it complex, since the biological feature of tumor cell must be considered carefully for drug selection. To make it straight, the latest strategies for breast cancer treatment based on both basic and clinical evidences are summarized, especially about surgical and medical treatments of primary therapy for breast cancer.
针对乳腺癌的积极临床研究显著推进了治疗策略,然而,由于其多样性,基于证据为每位患者选择合适的治疗方法似乎更加困难。此外,基础研究确立的各种分子靶向药物取得的显著成果也使其变得复杂,因为在选择药物时必须仔细考虑肿瘤细胞的生物学特性。为了阐述清楚,本文总结了基于基础和临床证据的乳腺癌最新治疗策略,特别是关于乳腺癌初始治疗的手术和药物治疗。