Pleteneva E A, Shaburova O V, Azeredo J, Krylov V N
Genetika. 2010 Apr;46(4):563-7.
The influence of infection of natural isolates of Salmonella enterica with lytic (nonlysogenic) phages on the expression of resident cryptic or defective prophages in host bacteria was studied. The induction of defective/cryptic phages after infection with nonlysogenic phages and packaging of bacterial chromosomal fragments in capsids of defective phages is demonstrated. This may lead to migration and wide distribution of both the genomes of defective phages per se and various fragments of the bacterial chromosome (including pathogenic islands) in new bacterial strains with concomitant change of their properties, the acquired new features of pathogenicity among them.
研究了肠道沙门氏菌自然分离株被裂解性(非溶原性)噬菌体感染对宿主细菌中常驻隐匿性或缺陷性原噬菌体表达的影响。证实了非溶原性噬菌体感染后缺陷性/隐匿性噬菌体的诱导以及细菌染色体片段在缺陷性噬菌体衣壳中的包装。这可能导致缺陷性噬菌体本身的基因组以及细菌染色体的各种片段(包括致病岛)在新的细菌菌株中迁移和广泛分布,同时伴随其特性的改变,其中包括获得新的致病性特征。