Dua Rakesh K, Devi B Indira, Yasha T C
Department of Neurosurgery, NIMHANS, Bangalore, India.
Br J Neurosurg. 2010 Aug;24(4):454-9. doi: 10.3109/02688691003739873.
Aquaporins and astrocytes are important in maintaining water hemostasis in brain. Upregulation of AQP-4 has been described in conditions associated with brain edema.
To study the expression of aquaporin-4 in brain tumors and its correlation with contrast enhancement and perilesional edema.
30 cases of brain tumors, both benign and malignant were included in the study to look for expression of AQP-4.
AQP-4 expression was increased in brain tumors compared to normal brain but distribution and intensity of expression depend upon the type of tumor. A trend toward increased AQP-4 expression in enhancing lesions with perilesional edema was noticed.
AQP-4 expression was seen in tumor tissue and perilesional reactive astrocytes in primary brain tumors, however only perilesional astrocytes showed positivity in secondary brain tumors. AQP-4 could be playing a role in alteration of blood-brain barrier leading to contrast enhancement and perilesional edema. Increased knowledge of Aquaporins may open new targeted therapy for brain edema.
水通道蛋白和星形胶质细胞在维持脑内水平衡中起重要作用。在与脑水肿相关的情况下，AQP-4表达上调已有报道。
研究水通道蛋白-4在脑肿瘤中的表达及其与增强扫描和瘤周水肿的相关性。
本研究纳入30例脑肿瘤患者，包括良性和恶性肿瘤，以观察AQP-4的表达情况。
与正常脑相比，脑肿瘤中AQP-4表达增加，但表达的分布和强度取决于肿瘤类型。在伴有瘤周水肿的强化病灶中，观察到AQP-4表达有增加趋势。
在原发性脑肿瘤的肿瘤组织和瘤周反应性星形胶质细胞中可见AQP-4表达，然而在继发性脑肿瘤中仅瘤周星形胶质细胞呈阳性。AQP-4可能在血脑屏障改变导致增强扫描和瘤周水肿中起作用。对水通道蛋白的进一步了解可能为脑水肿开辟新的靶向治疗方法。
