水通道蛋白在人脑肿瘤细胞迁移和水肿形成中的作用。

Role of aquaporins in cell migration and edema formation in human brain tumors.

机构信息

Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy.

出版信息

Exp Cell Res. 2011 Oct 15;317(17):2391-6. doi: 10.1016/j.yexcr.2011.07.006. Epub 2011 Jul 20.

DOI:10.1016/j.yexcr.2011.07.006

Abstract

The aquaporins (AQPs) are a family of transmembrane water channel proteins widely distributed and play a major role in transcellular and transepithelial water movement. Moreover, recent evidence indicates that AQPs may be involved in cell migration, angiogenesis, and tumor growth. This review article summarizes literature data concerning the involvement of AQP-1 and -4 in human brain tumor growth and edema formation and suggests a potential therapeutic approach by antagonizing their biological activity.

摘要

水通道蛋白（AQPs）是一组广泛分布的跨膜水通道蛋白，在细胞间和上皮细胞间的水运动中起主要作用。此外，最近的证据表明 AQPs 可能参与细胞迁移、血管生成和肿瘤生长。本文综述了有关 AQP-1 和 -4 参与人脑肿瘤生长和水肿形成的文献数据，并提出了通过拮抗其生物学活性来抑制肿瘤生长和水肿形成的潜在治疗方法。