Laboratory of Proteomics, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Expert Rev Proteomics. 2010 Jun;7(3):333-45. doi: 10.1586/epr.10.22.
Mitochondria are organelles that are essential for cell life and death. A huge range of pathologies, including neurodegenerative diseases, cancer, diabetes and aging, have been reported to be associated with mitochondrial dysfunction. Therefore, identification of mitochondrial proteins that are differentially expressed in these pathologies will help to further our understanding of these diseases. In recent years, great achievements have been made in mammalian mitochondrial proteomics. Here we provide an overview of the current state of knowledge with respect to the whole mitochondrial proteome, the mitochondrial subproteome, mitochondrial complexes and mitochondrial post-translational modifications. Applications of comparative mitochondrial proteomics to various pathologies that have provided clues for understanding the relationship between mitochondrial dysfunction and pathogenesis are described. We conclude that mitochondrial proteomics can be used not only to map all the components of mitochondria, but can also provide information for discovering therapeutic targets for mitochondria-related diseases.
线粒体是细胞生命和死亡所必需的细胞器。大量的病理学研究，包括神经退行性疾病、癌症、糖尿病和衰老，都与线粒体功能障碍有关。因此，鉴定这些疾病中线粒体蛋白的差异表达将有助于我们进一步了解这些疾病。近年来，哺乳动物线粒体蛋白质组学取得了巨大的成就。在这里，我们概述了整个线粒体蛋白质组、线粒体亚蛋白质组、线粒体复合物和线粒体翻译后修饰的最新知识状态。比较线粒体蛋白质组学在各种病理学中的应用为理解线粒体功能障碍与发病机制之间的关系提供了线索。我们得出的结论是，线粒体蛋白质组学不仅可以用于绘制线粒体的所有成分图谱，还可以为发现与线粒体相关疾病的治疗靶点提供信息。
