Institute of Nephrology, Zhong Da Hospital, Southeast University, Nanjing, Jiangsu Province, China.
Biomarkers. 2010 Sep;15(6):533-7. doi: 10.3109/1354750X.2010.493973.
To determine the clinical value of B-type natriuretic peptide (BNP) in diagnosing left ventricular diastolic dysfunction (LVDD) associated with maintenance haemodialysis (MHD) population.
Plasma BNP was determined in 59 MHD patients with normal ejection fraction. The ratio of early to late annular velocity (E'/A') was determined by tissue Doppler imaging as a parameter of diastolic function.
LVDD occurred in 66% of the patients. Receiver-operating characteristic curve analyses identified a cut-off of 353.6 pg ml(-1) as the one with the highest sensitivity and specificity for detecting LVDD.
Plasma BNP may serve as a potential biomarker in diagnosing LVDD in MHD patients with normal systolic function.
确定 B 型利钠肽（BNP）在诊断维持性血液透析（MHD）人群左心室舒张功能障碍（LVDD）中的临床价值。
测定 59 例射血分数正常的 MHD 患者的血浆 BNP。组织多普勒成像测定早期与晚期环速度比（E'/A'）作为舒张功能参数。
LVDD 发生率为 66%。受试者工作特征曲线分析确定 353.6 pg ml(-1)为最佳截断值，用于检测 LVDD 的敏感性和特异性最高。
血浆 BNP 可作为诊断收缩功能正常的 MHD 患者 LVDD 的潜在生物标志物。
