Department of Dermatology, Asahikawa Medical College, Asahikawa, Japan.
J Dermatol. 2010 May;37(5):471-4. doi: 10.1111/j.1346-8138.2010.00861.x.
Tumor necrosis factor-alpha (TNF-alpha) antagonists are effective for inflammatory diseases, such as Crohn's disease, rheumatoid arthritis (RA) and psoriasis. Although TNF-alpha antagonists are also useful for sarcoidosis, paradoxical occurrence of sarcoidosis or sarcoidal reaction may be observed. We report a Crohn's disease patient, who developed sarcoidosis during infliximab therapy. A 35-year-old man had been receiving infliximab for 7 months for Crohn's disease. He developed cough and fever, accompanied by an infiltrated erythematous plaque on his right knee. The chest radiography, skin biopsy and laboratory findings were all consistent with sarcoidosis.
肿瘤坏死因子-α（TNF-α）拮抗剂对炎症性疾病如克罗恩病、类风湿关节炎（RA）和银屑病有效。尽管 TNF-α拮抗剂对结节病也有一定疗效，但可能会出现结节病或类肉瘤反应的矛盾现象。我们报告了一例克罗恩病患者在英夫利昔单抗治疗期间发生结节病。一名 35 岁男性因克罗恩病接受英夫利昔单抗治疗 7 个月。他出现咳嗽和发热，右膝出现浸润性红斑斑块。胸部 X 线摄影、皮肤活检和实验室检查结果均符合结节病。
