Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
J Dermatol. 2010 Jun;37(6):512-21. doi: 10.1111/j.1346-8138.2009.00771.x.
Psychological stress adversely affects the immune system, and aggravates various skin diseases, such as psoriasis, alopecia areata and atopic dermatitis. However, the precise underlying mechanisms remain to be elucidated. The goal of this study was to use a murine restraint stress model to determine the mechanisms by which psychological stress modulates immune response in contact dermatitis. In the present study, mice were sensitized and challenged on the skin with 2,4-dinitrofluorobenzene. Acute restraint stress was administrated to healthy or sensitized mice before challenge, and nuclear factor (NF)-kappaB DNA-binding activation of nuclear protein and expression of interleukin (IL)-18 mRNA in murine spleen lymphocytes was detected. Chemical sympathectomy was performed using the neurotoxin 6-hydroxy-dopamine to determine the effect of the sympathetic nervous system. The experiment showed that restraint stress induced a series of changes which include increasing of NF-kappaB DNA-binding activity and IL-18 mRNA expression in spleen lymphocytes and enhancement of contact hypersensitivity response, and these changes may be mediated by the sympathetic nervous system. These findings provide new insights into the roles of the nervous system in the aggravation of skin diseases.
心理压力会对免疫系统产生不良影响，并加重各种皮肤疾病，如银屑病、斑秃和特应性皮炎。然而，其确切的潜在机制仍有待阐明。本研究旨在使用小鼠束缚应激模型来确定心理压力调节接触性皮炎免疫反应的机制。在本研究中，使用 2,4-二硝基氟苯对小鼠进行致敏和皮肤挑战。在挑战前，对健康或致敏的小鼠进行急性束缚应激处理，并检测核因子（NF）-kappaB 核蛋白的 DNA 结合活性和小鼠脾淋巴细胞中白细胞介素（IL）-18 mRNA 的表达。使用神经毒素 6-羟基多巴胺进行化学交感神经切除术，以确定交感神经系统的影响。实验表明，束缚应激会导致一系列变化，包括脾淋巴细胞中 NF-kappaB DNA 结合活性和 IL-18 mRNA 表达的增加，以及接触超敏反应的增强，这些变化可能是由交感神经系统介导的。这些发现为神经系统在皮肤疾病加重中的作用提供了新的见解。
