Department of Dermatology, Toho University Ohashi Medical Center, Meguro-ku, Tokyo, Japan.
J Dermatol. 2010 Jun;37(6):545-9. doi: 10.1111/j.1346-8138.2010.00831.x.
Endometriosis is a condition in which endometrium or endometrium-like tissue grows in areas other than the endometrium and is often found within the pelvis such as in the uterus or ovary, but occasionally develops ectopically in the skin. In this paper, we report a case of cutaneous endometriosis in the umbilical region found in a 37-year-old woman with no history of pregnancy. The lesion was a brown, firm and elastic nodule, 9 mm x 7 mm in size, and caused bleeding as well as pain which increased during menstruation. Histopathological findings revealed that there were small and large glandular cavity structures in the dermis and the edematous interstitium around it. On immunohistochemical staining for estrogen and progesterone receptors, the cellular nuclei of glandular cavity walls were mainly found to be positive for both, and cells in the edematous interstitium around the glandular cavity were positive for CD10. Consequently, we diagnosed this case as cutaneous endometriosis in the umbilical region. CD10 was initially described as a tumor-specific antigen found in acute lymphoblastic leukemia. Recently, the usefulness of CD10 in diagnosing endometriosis in addition to various types of lymphoma or blood cancer has been confirmed, and in our case it also proved to be as useful as estrogen receptor or progesterone receptor in the definitive diagnosis of endometriosis.
子宫内膜异位症是一种子宫内膜或类似子宫内膜的组织生长在子宫内膜以外的部位的疾病，通常在盆腔内发现，如子宫或卵巢，但偶尔也会异位生长在皮肤中。在本文中，我们报告了一例 37 岁无妊娠史女性脐部皮肤子宫内膜异位症病例。病变为 9mmx7mm 大小的棕色、坚实、有弹性的小结节，引起出血和疼痛，在月经期加重。组织病理学检查显示真皮内有小的和大的腺体腔结构，周围有水肿的间质。雌激素和孕激素受体免疫组化染色显示，腺体腔壁的细胞细胞核主要对两者均为阳性，而腺体腔周围水肿间质中的细胞对 CD10 为阳性。因此，我们诊断该病例为脐部皮肤子宫内膜异位症。CD10 最初被描述为在急性淋巴细胞白血病中发现的肿瘤特异性抗原。最近，CD10 在诊断子宫内膜异位症以及各种类型的淋巴瘤或血液癌中的作用已得到证实，在我们的病例中，它在子宫内膜异位症的明确诊断中与雌激素受体或孕激素受体一样有用。
