Department of Biochemistry, Boston University Medical School, Boston, Massachusetts, USA.
Ann N Y Acad Sci. 2010 Jun;1197:152-7. doi: 10.1111/j.1749-6632.2010.05196.x.
Various heat shock proteins, including Hsp72, are strongly upregulated in cancers, but their significance for tumor emergence and growth is poorly understood. Here we review recent data from several labs to indicate that Hsps, including Hsp72, are critical for growth of transformed but not normal cells. By manipulating expression and activity of Hsp72 and several oncogenes, it was shown that Hsp72 suppresses oncogene-induced senescence, thus allowing proliferation of cancer cells. Importantly, Hsp72 is able to suppress both p53-dependent and p53-independent senescence pathways. We propose that targeting Hsp72 may be a promising approach toward development of novel cancer therapies.
各种热休克蛋白，包括 Hsp72，在癌症中强烈上调，但它们对肿瘤发生和生长的意义还不清楚。在这里，我们回顾了来自几个实验室的最新数据，表明包括 Hsp72 在内的热休克蛋白对于转化细胞的生长而不是正常细胞的生长是至关重要的。通过操纵 Hsp72 和几种癌基因的表达和活性，研究表明 Hsp72 抑制癌基因诱导的衰老，从而允许癌细胞增殖。重要的是，Hsp72 能够抑制 p53 依赖和非依赖的衰老途径。我们提出，针对 Hsp72 可能是开发新的癌症治疗方法的一种有前途的方法。
