Arthritis Res Ther. 2010;12(3):120. doi: 10.1186/ar2998. Epub 2010 May 28.
Systemic lupus erythematosus (SLE) is a clinically and serologically complex disease that demonstrates clinical, epidemiological and genetic differences among racial and ethnic groups. Some autoantibodies are useful for diagnosis of the illness. Others are clinically important because of associations with a particular manifestation of SLE. Antibodies to RNA helicase A (anti-RHA) comprise a newly described class of SLE autoantibodies. These antibodies have so far been found only in SLE patients and differ substantially in prevalence and nature between Mexican and white American SLE patients. Study of anti-RHA may provide insights into the origin of population differences in SLE.
系统性红斑狼疮（SLE）是一种临床表现和血清学均较为复杂的疾病，在不同种族和民族之间存在临床、流行病学和遗传学差异。一些自身抗体有助于该病的诊断。另一些自身抗体与 SLE 的特定表现有关，因此具有重要的临床意义。抗 RNA 解旋酶 A（抗-RHA）抗体是一类新描述的 SLE 自身抗体。这些抗体迄今为止仅在 SLE 患者中发现，且在墨西哥和美国白人 SLE 患者中的患病率和性质存在显著差异。对抗-RHA 的研究可能有助于深入了解 SLE 患者人群差异的起源。
