Centre Ophtalmologique d'Imagerie et de Laser, 11 Rue Antoine Bourdelle, Paris, France.
Am J Ophthalmol. 2010 Aug;150(2):211-217.e1. doi: 10.1016/j.ajo.2010.02.019.
To report the presence of pseudocysts in retinal layers of eyes with geographic atrophy (GA) attributable to age-related macular degeneration (AMD) and to estimate their prevalence.
Retrospective study.
setting: Clinical practice. patients: Consecutive patients with GA, assessed by spectral-domain optical coherence tomography (OCT). main outcome measures: Assessment of pseudocyst prevalence in retinal layers. Statistical analysis by the chi(2) test, Fisher exact test, Mann-Whitney U test, and Cramer test, performed to explore links between the presence of pseudocysts and demographic features and/or pattern of atrophy, ie, horseshoe, homogeneous area, homogeneous area or patchy atrophy with foveal sparing, and patchy atrophy.
Eighty-eight eyes of 68 GA patients aged between 61 and 94 years (mean: 79.8) were examined. In 20 patients, GA was bilateral. Twenty-four eyes (27.2%) exhibited pseudocysts corresponding to small cystoid spaces frequently located in the inner nuclear layer of the retina. There was no macular edema. Fluorescein angiography, performed in 71 eyes (80%), ruled out possible choroidal neovascularization. No correlation was found between 1) patients' age (P = .7) or gender (P > .99) and the presence of pseudocysts or 2) patterns of atrophy (Cramer test: V = 0.183) and the presence of pseudocysts.
Pseudocysts seemed to be frequent in atrophic AMD. They might correspond to Müller cell degeneration, as suspected in other degenerative retinal disorders like tamoxifen retinopathy or group 2A idiopathic juxtafoveolar retinal telangiectasis. The present results indicate that pseudocysts are frequently seen on OCT in eyes with atrophic AMD and their presence should not be considered as a manifestation of neovascular AMD that requires prompt treatment.
报告年龄相关性黄斑变性（AMD）所致地图状萎缩（GA）眼视网膜层假性囊肿的存在，并估计其患病率。
回顾性研究。
设置：临床实践。患者：连续接受光谱域光学相干断层扫描（OCT）评估的 GA 患者。主要观察指标：评估视网膜各层假性囊肿的患病率。采用卡方检验、Fisher 确切检验、Mann-Whitney U 检验和 Cramer 检验进行统计学分析，以探讨假性囊肿的存在与人口统计学特征和/或萎缩模式（马蹄形、均匀区、均匀区或伴有黄斑 spared 的斑片状萎缩、斑片状萎缩）之间的关系。
共检查了 68 例 GA 患者的 88 只眼，年龄在 61 岁至 94 岁之间（平均 79.8 岁）。20 例患者为双眼 GA。24 只眼（27.2%）出现假性囊肿，对应于常位于视网膜内核层的小囊状间隙。无黄斑水肿。71 只眼（80%）行荧光素血管造影，排除了可能的脉络膜新生血管。未发现 1）患者年龄（P=0.7）或性别（P＞0.99）与假性囊肿的存在之间，或 2）萎缩模式（Cramer 检验：V=0.183）与假性囊肿的存在之间存在相关性。
假性囊肿在萎缩性 AMD 中似乎较为常见。它们可能与 Müller 细胞变性有关，在其他退行性视网膜疾病中也有类似的发现，如他莫昔芬性视网膜病变或 2A 型特发性黄斑旁视网膜毛细血管扩张症。本研究结果表明，在萎缩性 AMD 眼中，OCT 上经常可见假性囊肿，其存在不应被视为需要立即治疗的新生血管 AMD 的表现。
