栀子黄色素对睡眠的影响：一项初步研究。

Effect of crocetin from Gardenia jasminoides Ellis on sleep: a pilot study.

机构信息

Department of Health Science, Faculty of Health Science for Welfare, Kansai University of Welfare Sciences, Kashiwara, Osaka, Japan.

出版信息

Phytomedicine. 2010 Sep;17(11):840-3. doi: 10.1016/j.phymed.2010.03.025.

DOI:10.1016/j.phymed.2010.03.025

PMID:20537515

Abstract

Crocetin is a pharmacologically active carotenoid compound of Gardenia jasminoides Ellis used as a traditional herbal medicine and natural colorant. The present pilot study investigated the effect of crocetin on sleep. The clinical trial comprised a double-blind, placebo-controlled, crossover trial of 21 healthy adult men with a mild sleep complaint. It included two intervention periods of 2 weeks each, separated by a 2-week washout period. We measured objective sleep quality using an actigraph, and assessed the subjective symptoms using St Mary's Hospital Sleep Questionnaire. Actigraph data showed that after administration of crocetin, the number of wakening episodes was reduced compared to that of the placebo (p=0.025). Subjective data from St Mary's Hospital Sleep Questionnaire showed that crocetin tended to improve the quality of sleep compared to sleep before its intake. Additionally, no side effects from crocetin intake were observed. The results suggest that crocetin may contribute to improving the quality of sleep.

摘要

西红花酸是栀子中的一种具有药理活性的类胡萝卜素化合物，被用作传统草药和天然着色剂。本初步研究调查了西红花酸对睡眠的影响。临床试验包括一项双盲、安慰剂对照、交叉试验，共有 21 名有轻度睡眠抱怨的健康成年男性参加，每个干预期为 2 周，间隔 2 周洗脱期。我们使用活动记录仪测量客观睡眠质量，并使用圣玛丽医院睡眠问卷评估主观症状。活动记录仪数据显示，与安慰剂相比，西红花酸给药后觉醒次数减少（p=0.025）。圣玛丽医院睡眠问卷的主观数据显示，与摄入西红花酸之前相比，西红花酸倾向于改善睡眠质量。此外，未观察到西红花酸摄入的副作用。结果表明，西红花酸可能有助于改善睡眠质量。