Oliveira Hélder, Cai Xiaoshuang, Zhang Qian, de Freitas Victor, Mateus Nuno, He Jingren, Fernandes Iva
REQUIMTE/LAQV, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal.
Food Funct. 2017 Apr 19;8(4):1672-1679. doi: 10.1039/c7fo00091j.
The gastrointestinal absorption of the main carotenoids present in Gardenia jasminoides Ellis, crocetin, crocin-1 and crocin-2, was assayed through transport studies on MKN-28 and Caco-2 cell lines. Overall, crocetin was the compound that presented the highest gastrointestinal transport efficiency. Additionally, and since after absorption crocins are metabolized into crocetin, the antiproliferative capacity of crocetin was assayed in MKN-28 (stomach), MCF-7 (breast) and Caco-2 (colon) cancer cell lines. The results point to an antiproliferative effect of crocetin on the three cell lines tested. Anti-inflammatory properties were also assayed. Overall, crocetin showed a potential involvement in the downregulation of IL-1β and TNF-α but not IL-6. Altogether, these results suggest that these compounds can have an important role against cancer proliferation, highlighting the importance of Gardenia jasminoides Ellis as a nutraceutical food source.
通过对MKN - 28和Caco - 2细胞系进行转运研究，测定了栀子中主要类胡萝卜素西红花酸、藏红花素 - 1和藏红花素 - 2的胃肠道吸收情况。总体而言，西红花酸是胃肠道转运效率最高的化合物。此外，由于吸收后藏红花素会代谢为西红花酸，因此在MKN - 28（胃）、MCF - 7（乳腺）和Caco - 2（结肠）癌细胞系中测定了西红花酸的抗增殖能力。结果表明西红花酸对所测试的三种细胞系均有抗增殖作用。还测定了其抗炎特性。总体而言，西红花酸显示出可能参与白细胞介素 - 1β和肿瘤坏死因子 - α的下调，但不参与白细胞介素 - 6的下调。总之，这些结果表明这些化合物可能在对抗癌症增殖方面发挥重要作用，突出了栀子作为营养食品来源的重要性。
Zotero 插件