Department of Obstetrics and Gynecology, University Clinic of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
Fertil Steril. 2010 Nov;94(6):2382-4. doi: 10.1016/j.fertnstert.2010.04.025. Epub 2010 May 26.
Ongoing pregnancy rate (PR) per randomized woman was found to be significantly lower in patients with oral contraceptive (OC) pill pretreatment (relative risk: 0.80, 95% confidence interval [CI]: 0.66-0.97; rate difference: -5%, 95% CI: -10% to -1%; fixed effects model) after pooling data from six randomized controlled trials encompassing 1,343 patients. Duration of stimulation (weighted mean difference [WMD]: +1.33 days, 95% CI: +0.61-2.05) and gonadotropin consumption (WMD: +360 IUs, 95% CI: +158-563) were significantly increased after OC pretreatment, but there was no statistically significant gain in the number of cumulus-oocyte complexes (WMD: +0.6 cumulus-oocyte complexes, 95% CI: -0.08-1.25).
在汇总了涵盖 1343 名患者的六项随机对照试验的数据后，我们发现，与未进行口服避孕药（OC）预处理的患者相比，OC 预处理患者的随机化女性的持续妊娠率（PR）显著降低（相对风险：0.80，95%置信区间 [CI]：0.66-0.97；率差：-5%，95%CI：-10%至-1%；固定效应模型）。预处理 OC 后，刺激持续时间（加权均数差 [WMD]：+1.33 天，95%CI：+0.61-2.05）和促性腺激素消耗（WMD：+360IU，95%CI：+158-563）显著增加，但卵丘-卵母细胞复合物的数量并没有显著增加（WMD：+0.6 个卵丘-卵母细胞复合物，95%CI：-0.08-1.25）。
