Chapelon-Abric C, Wajman A, Villarroya A, Godeau P
Service Médecine Interne, Hôpital Pitié, Paris.
Ann Cardiol Angeiol (Paris). 1991 Apr;40(4):215-8.
The antihypertensive action of sustained release verapamil is, in the majority of cases, obtained with a dosage of 240 mg per day. In certain patients, it is necessary to increase the daily dose to 360 or even 480 mg. This dosage increase most often leads to twice daily administration. In the present trial (18 patients included), the efficacy 360 mg of sustained release verapamil was compared double-blind with that of 360 mg as two divided doses. The antihypertensive action of sustained release verapamil as a single dose was shown to be identical to that of two daily doses. It is therefore felt to be unnecessary to increase the number of daily doses in parallel with dosage increases. There is absolutely no doubt that single dose monotherapy leads to better compliance.
大多数情况下，缓释维拉帕米的降压作用通过每日240毫克的剂量即可实现。在某些患者中，有必要将每日剂量增加至360毫克甚至480毫克。这种剂量增加通常会导致每日给药两次。在本试验（纳入18名患者）中，将360毫克缓释维拉帕米的疗效与360毫克分两次给药的疗效进行了双盲比较。结果显示，缓释维拉帕米单次给药的降压作用与每日两次给药相同。因此，认为没有必要随着剂量增加而增加每日给药次数。毫无疑问，单剂量单一疗法可带来更好的依从性。
