Faculty of Medicine, University of Porto, Porto, Portugal.
Forensic Sci Int. 2010 Oct 10;202(1-3):e23-7. doi: 10.1016/j.forsciint.2010.04.047. Epub 2010 May 26.
Psychiatric deviations resulting from alcohol and illegal drug abuse may be considered a major risk factor for suicidal behavior. This report describes a suicide by hanging, under the influence of ketamine and alcohol. The victim was a 29-year-old man, found dead hanging by the neck from a metallic beam in the ceiling of his workplace. Besides characteristic signs of hanging seen at the autopsy, toxicological analysis revealed a femoral blood concentration of ketamine and ethanol of 1.3mg/L and 0.66g/L, respectively. Positive qualitative results for ketamine were also detected, in a powder found near the victim and on the victim's nostrils, which suggests nasal inhaling as administration route. The hallucinogenic effects caused by ketamine, associated with an increased sensitivity of N-methyl-d-aspartate (NMDA) receptors to ketamine as result of the previous history of alcoholism should be considered as potential inducing factors in suicide behaviors.
因酗酒和滥用非法药物导致的精神障碍可被视为自杀行为的一个主要危险因素。本报告描述了一起由氯胺酮和酒精影响下的自杀上吊事件。受害者是一名 29 岁男性，被发现死于工作场所天花板金属梁上的自缢。除了尸检时发现的典型的自缢迹象外，毒理学分析显示股动脉血液中的氯胺酮和乙醇浓度分别为 1.3mg/L 和 0.66g/L。在靠近受害者和受害者鼻孔处发现的粉末中，以及在受害者的鼻孔中均检测到氯胺酮呈阳性定性结果，提示鼻内吸入是给药途径。氯胺酮引起的致幻作用，以及由于先前的酗酒史导致 N-甲基-D-天冬氨酸（NMDA）受体对氯胺酮的敏感性增加，应被视为自杀行为的潜在诱导因素。
