充分利用有机溶质转运体（OST）：有机溶质转运体α-OSTβ在胆汁酸和类固醇代谢中的作用。
Getting the mOST from OST: Role of organic solute transporter, OSTalpha-OSTbeta, in bile acid and steroid metabolism.
作者信息
Dawson Paul A, Hubbert Melissa L, Rao Anuradha
机构信息
Department of Internal Medicine, Section on Gastroenterology, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA.
出版信息
Biochim Biophys Acta. 2010 Sep;1801(9):994-1004. doi: 10.1016/j.bbalip.2010.06.002. Epub 2010 Jun 9.
Abstract
The organic solute transporter (OST)(alpha)-OST(beta) is an unusual heteromeric carrier expressed in a variety of tissues including the small intestine, colon, liver, biliary tract, kidney, and adrenal gland. In polarized epithelial cells, OSTalpha-OSTbeta protein is localized on the basolateral membrane and functions in the export or uptake of bile acids and steroids. This article reviews recent results including studies of knockout mouse models that provide new insights to the role of OSTalpha-OSTbeta in the compartmentalization and metabolism of these important lipids.
摘要
有机溶质转运体（OST）（α）-OST（β）是一种特殊的异源寡聚载体，在包括小肠、结肠、肝脏、胆道、肾脏和肾上腺在内的多种组织中表达。在极化上皮细胞中，OSTα-OSTβ蛋白定位于基底外侧膜，在胆汁酸和类固醇的输出或摄取中发挥作用。本文综述了近期的研究结果，包括对基因敲除小鼠模型的研究，这些研究为OSTα-OSTβ在这些重要脂质的区室化和代谢中的作用提供了新的见解。
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2
Hepatocyte nuclear factor 1alpha and beta control terminal differentiation and cell fate commitment in the gut epithelium.
Development. 2010 May;137(9):1573-82. doi: 10.1242/dev.044420.
3
Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine.
Hepatology. 2010 Apr;51(4):1410-9. doi: 10.1002/hep.23450.
4
Mouse organic solute transporter alpha deficiency enhances renal excretion of bile acids and attenuates cholestasis.
Hepatology. 2010 Jan;51(1):181-90. doi: 10.1002/hep.23265.
5
Asparagine-linked oligosaccharides present on a non-consensus amino acid sequence in the CH1 domain of human antibodies.
J Biol Chem. 2009 Nov 20;284(47):32493-506. doi: 10.1074/jbc.M109.014803. Epub 2009 Sep 18.
6
Compensatory role of P-glycoproteins in knockout mice lacking the bile salt export pump.
Hepatology. 2009 Sep;50(3):948-56. doi: 10.1002/hep.23089.
7
Bile salts of vertebrates: structural variation and possible evolutionary significance.
J Lipid Res. 2010 Feb;51(2):226-46. doi: 10.1194/jlr.R000042. Epub 2009 Jul 28.
8
Targeted metabolomics identifies glucuronides of dietary phytoestrogens as a major class of MRP3 substrates in vivo.
Gastroenterology. 2009 Nov;137(5):1725-35. doi: 10.1053/j.gastro.2009.06.052. Epub 2009 Jul 3.
9
Expression and regulation of the bile acid transporter, OSTalpha-OSTbeta in rat and human intestine and liver.
Biopharm Drug Dispos. 2009 Jul;30(5):241-58. doi: 10.1002/bdd.663.
10
Bile acid transporters.
J Lipid Res. 2009 Dec;50(12):2340-57. doi: 10.1194/jlr.R900012-JLR200. Epub 2009 Jun 4.
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