Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Neurobiol Aging. 2010 Aug;31(8):1284-303. doi: 10.1016/j.neurobiolaging.2010.05.003. Epub 2010 Jun 11.
Cerebrospinal fluid (CSF) measures of Ab and tau, Pittsburgh Compound B (PIB) imaging and hippocampal atrophy are promising Alzheimer's disease biomarkers yet the associations between them are not known. We applied a validated, automated hippocampal labeling method and 3D radial distance mapping to the 1.5T structural magnetic resonance imaging (MRI) data of 388 ADNI subjects with baseline CSF Ab(42), total tau (t-tau) and phosphorylated tau (p-tau(181)) and 98 subjects with positron emission tomography (PET) imaging using PIB. We used linear regression to investigate associations between hippocampal atrophy and average cortical, parietal and precuneal PIB standardized uptake value ratio (SUVR) and CSF Ab(42), t-tau, p-tau(181), t-tau/Ab(42) and p-tau(181)/Ab(42). All CSF measures showed significant associations with hippocampal volume and radial distance in the pooled sample. Strongest correlations were seen for p-tau(181), followed by p-tau(181)/Ab(42) ratio, t-tau/Ab(42) ratio, t-tau and Ab(42). p-tau(181) showed stronger correlation in ApoE4 carriers, while t-tau showed stronger correlation in ApoE4 noncarriers. Of the 3 PIB measures the precuneal SUVR showed strongest associations with hippocampal atrophy.
脑脊液 (CSF) 中的 Ab 和 tau 测量、匹兹堡化合物 B (PIB) 成像和海马体萎缩是有前途的阿尔茨海默病生物标志物，但它们之间的关联尚不清楚。我们应用了一种经过验证的、自动化的海马体标记方法和三维放射状距离映射，对 388 名 ADNI 受试者的 1.5T 结构磁共振成像 (MRI) 数据进行了分析，这些受试者在基线时进行了 CSF Ab(42)、总 tau (t-tau) 和磷酸化 tau (p-tau(181)) 测量，以及 98 名使用 PIB 进行正电子发射断层扫描 (PET) 成像的受试者。我们使用线性回归来研究海马体萎缩与平均皮质、顶叶和楔前叶 PIB 标准化摄取值比 (SUVR) 以及 CSF Ab(42)、t-tau、p-tau(181)、t-tau/Ab(42) 和 p-tau(181)/Ab(42) 之间的相关性。在合并样本中，所有 CSF 测量均与海马体体积和径向距离有显著相关性。p-tau(181) 相关性最强，其次是 p-tau(181)/Ab(42) 比值、t-tau/Ab(42) 比值、t-tau 和 Ab(42)。p-tau(181) 在 ApoE4 携带者中相关性更强，而 t-tau 在 ApoE4 非携带者中相关性更强。在这 3 种 PIB 测量中，楔前叶 SUVR 与海马体萎缩的相关性最强。
