Storandt Martha, Mintun Mark A, Head Denise, Morris John C
Department of Psychology, School of Arts and Sciences, Washington University, St Louis, Missouri 63108, USA.
Arch Neurol. 2009 Dec;66(12):1476-81. doi: 10.1001/archneurol.2009.272.
To examine the relation of amyloid-beta peptide (Abeta) levels in the cerebral cortex with structural brain integrity and cognitive performance in cognitively healthy older people.
Longitudinal study from May 22, 1985, through October 15, 2008.
Washington University Alzheimer Disease Research Center.
A total of 135 individuals aged 65 to 88 years with a Clinical Dementia Rating of 0.
The relations between mean cortical carbon 11 ((11)C)-labeled Pittsburgh compound B (PiB) binding potential values, proportional to the density of fibrillar Abeta binding sites in the brain, concurrent regional brain volumes as assessed by magnetic resonance imaging, and both concurrent and longitudinal cognitive performance in multiple domains.
Elevated cerebral Abeta levels, in some cases comparable to those seen in individuals with Alzheimer disease, were observed in 29 participants, who also had smaller regional volumes in the hippocampus, temporal neocortex, anterior cingulate, and posterior cingulate. Concurrent cognitive performance was unrelated to Abeta levels but was related to regional brain volumes with the exception of the caudate. Longitudinal cognitive decline in episodic and working memory and visuospatial ability was associated with elevated Abeta levels and decreased hippocampal volume.
The in vivo measure of cerebral amyloidosis known as [(11)C]PiB is associated with cross-sectional regionally specific brain atrophy and longitudinal cognitive decline in multiple cognitive domains that occur before the clinical diagnosis of Alzheimer disease. These findings contribute to the understanding of the cognitive and structural consequences of Abeta levels in cognitively healthy older adults.
研究认知功能正常的老年人大脑皮质中β淀粉样肽（Aβ）水平与脑结构完整性及认知表现之间的关系。
1985年5月22日至2008年10月15日的纵向研究。
华盛顿大学阿尔茨海默病研究中心。
135名年龄在65至88岁之间、临床痴呆评定量表评分为0的个体。
平均皮质碳11（¹¹C）标记的匹兹堡化合物B（PiB）结合潜能值（与大脑中纤维状Aβ结合位点的密度成正比）、通过磁共振成像评估的同期区域脑容量，以及多个领域的同期和纵向认知表现之间的关系。
在29名参与者中观察到大脑Aβ水平升高，在某些情况下与阿尔茨海默病患者的水平相当，这些参与者的海马体、颞叶新皮质、前扣带回和后扣带回的区域体积也较小。同期认知表现与Aβ水平无关，但与除尾状核外的区域脑容量有关。情景记忆、工作记忆和视觉空间能力的纵向认知衰退与Aβ水平升高和海马体体积减小有关。
称为[¹¹C]PiB的脑淀粉样变性的体内测量与阿尔茨海默病临床诊断之前出现的多个认知领域的横断面区域特异性脑萎缩和纵向认知衰退相关。这些发现有助于理解认知功能正常的老年人中Aβ水平对认知和结构的影响。
