Doktorov A A, Denisov-Nikol'skiĭ Iu I
Arkh Anat Gistol Embriol. 1991 Jan;100(1):68-74.
By means of scanning and transmissive electron microscopy methods structure of the developing bone has been studied. Interconnection of the cell structure and spatial organization of the adjoining matrix has been demonstrated. On the surface of the growing bone not only forming areas have been revealed, where under osteoblasts at various functional states, osteoid layer is determined, but also areas of resorption and completed osteogenesis. This demonstrates an interrupted character of osteogenesis at modelling. At the same time for the remodelling process presence of erosive lacunae is specific; they are filled with a newly deposited collagenous matrix. Therefore, it is possible to suppose that formation of the bone as an organ during the postnatal development includes in itself both mechanisms supporting its form at outgrowth of the osseous matrix volume (modeling) and its continuous rearrangement and adaptation to real conditions of functioning (remodelling).
通过扫描电子显微镜和透射电子显微镜方法研究了发育中骨骼的结构。已证实细胞结构与相邻基质的空间组织之间存在相互联系。在生长骨骼的表面，不仅发现了形成区域，在不同功能状态的成骨细胞下方可确定类骨质层，还发现了吸收区域和完成骨生成的区域。这表明在塑形过程中骨生成具有间断性。同时，对于重塑过程而言，侵蚀性腔隙的存在具有特异性；它们充满了新沉积的胶原基质。因此，可以推测出生后发育过程中骨骼作为一个器官的形成本身既包括在骨基质体积增加时支持其形态的机制（塑形），也包括其持续的重新排列和对实际功能条件的适应（重塑）。
