Marks S C, Popoff S N
Department of Anatomy, University of Massachusetts Medical School, Worcester 01655.
Am J Anat. 1988 Sep;183(1):1-44. doi: 10.1002/aja.1001830102.
Bone cells compose a population of cells of heterogeneous origin but restricted function with respect to matrix formation, mineralization, and resorption. The local, mesenchymal origin of the cells which form the skeleton contrasts with their extraskeletal, hemopoietic relatives under which bone resorption takes place. However, the functions of these two diverse populations are remarkably related and interdependent. Bone cell regulation, presently in its infancy, is a complicated cascade involving a plethora of local and systemic factors, including some components of the skeletal matrices and other organ systems. Thus, any understanding of bone cell regulation is a key ingredient in understanding not only the development, maintenance, and repair of the skeleton but also the prevention and treatment of skeletal disorders.
骨细胞由一群起源各异但在基质形成、矿化和吸收方面功能受限的细胞组成。形成骨骼的细胞起源于局部间充质，这与发生骨吸收的骨骼外造血相关细胞形成对比。然而，这两种不同细胞群体的功能显著相关且相互依存。骨细胞调节目前尚处于起步阶段，是一个复杂的级联过程，涉及大量局部和全身因素，包括骨骼基质和其他器官系统的一些成分。因此，对骨细胞调节的任何理解不仅是理解骨骼发育、维持和修复的关键因素，也是理解骨骼疾病预防和治疗的关键因素。
