Department of Neurology, University Hospital Schleswig-Holstein, University of Kiel, Kiel, Germany.
Science. 2010 Jun 11;328(5984):1412-5. doi: 10.1126/science.1188160.
A critical role in place learning has been attributed to place cells within the cornu ammonis 1 (CA1) sector of the hippocampus in rodents. The role of CA1 cells in the human hippocampus with regard to place learning remains elusive. Using a virtual Morris water maze, we investigated patients with acute transient global amnesia (TGA), a rare self-limiting dysfunction of the hippocampal system. Fourteen individuals with selective and focal lesions in the CA1 sector of the hippocampus showed a profound impairment in place learning. The size of the lesions and the duration of the TGA correlated with the deficit in the performance.
在啮齿动物的海马角回 1 区（CA1）中，位置细胞在位置学习中起着关键作用。然而，CA1 细胞在人类海马体中对于位置学习的作用仍然难以捉摸。我们使用虚拟 Morris 水迷宫研究了患有急性短暂性全球记忆障碍（TGA）的患者，这是海马系统的一种罕见的自限性功能障碍。14 名海马 CA1 区选择性和局灶性损伤的个体在位置学习方面表现出严重障碍。损伤的大小和 TGA 的持续时间与表现缺陷相关。
