Constantinoiu S, Bîrlă R, Iosif C, Cociu L, Gîndea C, Hoară P, Achim F
Clinica de Chirurgie Generală şi Esofagiană, Spitalul Clinic Sf. Maria, UMF Carol Davila, Bucureşti.
Chirurgia (Bucur). 2010 Mar-Apr;105(2):279-85.
Cholangiocarcinoma is a rare disease (0.15-0.16% in the general population). We present the case of a man, 64 years old, who was admitted to our clinic for emergency with intense jaundice, abdominal pain in the supra-umbilical region. Laboratory analysis revealed elevated total bilirubin (23.5 mg/dl), with predominant direct bilirubin and an increased serum level of alkaline phosphatase and GGT, AST, ALT. The abdominal CT shows an tumor infiltrating distal bile duct, with important dilatation of proximal biliary tree and enlarged retro pancreatic lymph node (8 mm). The first therapeutic procedure was an surgical exploration of the abdomen to asses the resectability of the tumor and an internal biliary drainage colecisto-gastrostomy to allow improving of patient's biological and clinical state and a latter radical operation, after remission of jaundice. After a month we performed cephalic duodenopancreatectomy. Pathology result: moderately differentiated adenocarcinoma of intestinal type (G2) pT2NOMO (stage II). The postoperative evolution was favorable encumbered by a small pancreatic fistula healed by conservative method.
胆管癌是一种罕见疾病(在普通人群中的发病率为0.15 - 0.16%)。我们报告一例64岁男性病例,该患者因严重黄疸、脐上区域腹痛紧急入院。实验室分析显示总胆红素升高(23.5mg/dl),以直接胆红素为主,血清碱性磷酸酶、γ-谷氨酰转肽酶、天门冬氨酸氨基转移酶和丙氨酸氨基转移酶水平升高。腹部CT显示肿瘤浸润远端胆管,近端胆管树明显扩张,胰后淋巴结肿大(8mm)。首次治疗程序是进行腹部手术探查以评估肿瘤的可切除性,并进行内胆管引流胆肠吻合术,以改善患者的生物学和临床状态,待黄疸消退后进行后续根治性手术。一个月后我们实施了胰头十二指肠切除术。病理结果:中度分化肠型腺癌(G2),pT2N0M0(II期)。术后恢复良好,有一小的胰瘘,经保守方法治愈。