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3-溴-4,5,6,7-四氢-1,2-苯并异恶唑衍生物的合成及其抗真菌性能

Synthesis and antifungal properties of 3-bromo-4,5,6,7-tetrahydro-1,2-benzoisoxazole derivatives.

作者信息

Napoletano M, Chiarino D, Sala A, Albini E, Pinasi C

机构信息

Laboratori di Ricerca Zambon Group, Milano, Italy.

出版信息

Farmaco. 1991 Jan;46(1):21-31.

PMID:2054039
Abstract

The synthesis of 3-bromo-4,5,6,7-tetrahydro-1,2-benzoisoxazole derivatives and their activity against human pathogen fungi are reported. In particular, compound 3,5-dibromo-6,7-dihydro-1,2-benzoisoxazol-4-(5H)-one showed a broad antifungal spectrum and good fungicidal activity against Trichophyton mentagrophytes.

摘要

报道了3-溴-4,5,6,7-四氢-1,2-苯并异恶唑衍生物的合成及其对人类病原真菌的活性。特别是，化合物3,5-二溴-6,7-二氢-1,2-苯并异恶唑-4-(5H)-酮显示出广谱抗真菌活性，对须癣毛癣菌具有良好的杀菌活性。

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