Merritt Bradley G, Snow Stephen N, Longley B Jack
Department of Dermatology, The University of North Carolina at Chapel Hill, 3100 Thurston-Bowles Bldg, CB 7287, Chapel Hill, NC 27599-7287, USA.
Cutis. 2010 May;85(5):254-8.
Several important cutaneous neoplasms present with basaloid cells in the dermis. Desmoplastic trichoepithelioma (DTE), infiltrative/morpheaform basal cell carcinoma (BCC), and microcystic adnexal carcinoma (MAC) are tumors in this category that may be difficult to differentiate, especially when evaluating thin biopsy specimens. An accurate diagnosis has important clinical implications. While DTE is a benign neoplasm with indolent behavior, infiltrative/morpheaform BCC and MAC can be highly aggressive, leading to substantial local destruction and potential metastasis. We present a patient with an unusual tumor demonstrating basaloid cells in the dermis and discuss the diagnostic approach for these lesions, emphasizing the potential role of cytokeratin 20 (CK20) in determining the need for Mohs micrographic surgery.
几种重要的皮肤肿瘤在真皮中可见基底样细胞。促结缔组织增生性毛发上皮瘤（DTE）、浸润性/硬斑病样基底细胞癌（BCC）和微囊性附属器癌（MAC）都属于这一类肿瘤，它们可能难以鉴别，尤其是在评估薄活检标本时。准确的诊断具有重要的临床意义。虽然DTE是一种行为惰性的良性肿瘤，但浸润性/硬斑病样BCC和MAC可能具有高度侵袭性，导致大量局部破坏并可能发生转移。我们报告一名患有罕见肿瘤的患者，该肿瘤在真皮中显示基底样细胞，并讨论这些病变的诊断方法，强调细胞角蛋白20（CK20）在确定是否需要进行莫氏显微外科手术方面的潜在作用。
