Heidarpour Mitra, Rajabi Parvin, Sajadi Farzaneh
Associate Professor, Department of Pathology, Isfahan University of Medical sciences, Isfahan, Iran.
J Res Med Sci. 2011 Jul;16(7):938-44.
The distinction between basal cell carcinoma (BCC) and trichoepithelioma (TE) may be very difficult in some cases because of the close similarities of these two lesions clinically and histopathologically. The purpose of this study is to investigate the usefulness of CD10 in distinguishing BCC and TE.
The immunohistochemical expression of CD10 was evaluated in an archived group of 30 BCCs and 12 TEs in a retrospective cross sectional study. The localization of anti-CD10 to the tumoral and/or stromal cells was determined in each case and was compared between these two tumors using Fisher's Exact Test.
In BCC cases, the expression of CD10 was noted in tumoral cells in 26 cases (83.2%). Of these, 3 cases showed positivity of the stromal and basaloid cells, two cases demonstrated stromal expression alone and two BCCs were not immunoreactive. On the other hand, 10 out of 12 (83.3%) TEs showed positive stromal immunoreactivity. Of these, one case also showed positivity of the basaloid cells. One TE demonstrated epithelial expression alone and one TE was not immunoreactive. The pattern of staining of basaloid cells and stromal cells in BCC and trichoepithelioma was statistically different (p < 0.001).
We conclude that CD10 is a useful marker in the differential diagnosis of BCC versus TE.
在某些情况下，基底细胞癌（BCC）和毛发上皮瘤（TE）的鉴别可能非常困难，因为这两种病变在临床和组织病理学上极为相似。本研究的目的是探讨CD10在鉴别BCC和TE中的作用。
在一项回顾性横断面研究中，对一组存档的30例BCC和12例TE进行CD10免疫组化表达评估。确定每例中抗CD10在肿瘤细胞和/或基质细胞中的定位，并使用Fisher精确检验在这两种肿瘤之间进行比较。
在BCC病例中，26例（83.2%）肿瘤细胞中观察到CD10表达。其中，3例基质细胞和基底样细胞呈阳性，2例仅基质表达阳性，2例BCC无免疫反应性。另一方面，12例TE中有10例（83.3%）基质免疫反应阳性。其中，1例基底样细胞也呈阳性。1例TE仅上皮表达阳性，1例TE无免疫反应性。BCC和毛发上皮瘤中基底样细胞和基质细胞的染色模式在统计学上有差异（p < 0.001）。
我们得出结论，CD10是鉴别BCC与TE的有用标志物。
