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Bivalent diketopiperazine-based tropomysin receptor kinase C (TrkC) antagonists.
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A peptidomimetic of NT-3 acts as a TrkC antagonist.
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Combinatorial assembly of small molecules into bivalent antagonists of TrkC or TrkA receptors.
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Neurodevelopment. Dendrite morphogenesis depends on relative levels of NT-3/TrkC signaling.
Science. 2014 Oct 31;346(6209):626-9. doi: 10.1126/science.1258996.

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Selective Modulation of Trk Receptors by -Organopeptides.
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Selective inhibitors of the TrkC.T1 receptor reduce retinal inflammation and delay neuronal death in a model of retinitis pigmentosa.
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Selective, Intrinsically Fluorescent Trk Modulating Probes.
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Neuroprotection: Pro-survival and Anti-neurotoxic Mechanisms as Therapeutic Strategies in Neurodegeneration.
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Targeted PDT agent eradicates TrkC expressing tumors via photodynamic therapy (PDT).
Mol Pharm. 2015 Jan 5;12(1):212-22. doi: 10.1021/mp5005564. Epub 2014 Dec 9.
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Combinatorial assembly of small molecules into bivalent antagonists of TrkC or TrkA receptors.
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Developing bivalent ligands to target CUG triplet repeats, the causative agent of myotonic dystrophy type 1.
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2
A peptidomimetic of NT-3 acts as a TrkC antagonist.
Peptides. 2009 Oct;30(10):1833-9. doi: 10.1016/j.peptides.2009.07.015. Epub 2009 Jul 30.
3
The biology of neurotrophins, signalling pathways, and functional peptide mimetics of neurotrophins and their receptors.
CNS Neurol Disord Drug Targets. 2008 Feb;7(1):46-62. doi: 10.2174/187152708783885174.
4
A combinatorial method for solution-phase synthesis of labeled bivalent beta-turn mimics.
J Am Chem Soc. 2008 Jan 16;130(2):556-65. doi: 10.1021/ja074717z. Epub 2007 Dec 19.
6
Selective formation of homo- and heterobivalent peptidomimetics.
J Med Chem. 2003 Aug 14;46(17):3565-7. doi: 10.1021/jm034103e.
7
Small molecule Trk receptor agonists and other neurotrophic factor mimetics.
Curr Drug Targets CNS Neurol Disord. 2002 Feb;1(1):59-80. doi: 10.2174/1568007023339490.
8
Design of potent peptide mimetics of brain-derived neurotrophic factor.
J Biol Chem. 2003 Jul 11;278(28):25738-44. doi: 10.1074/jbc.M303209200. Epub 2003 May 2.

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