Department of Chemistry, Texas A&M University, Box 30012, College Station, Texas 77842-3012, USA.
J Med Chem. 2010 Jul 8;53(13):5044-8. doi: 10.1021/jm100148d.
Bivalent molecules containing two beta-turn mimics with side chains that correspond to hot-spots on the neurotrophin NT-3 were prepared. Binding assays showed the mimetics to be selective TrkC ligands, and biological assays showed one mimetic to be an antagonist of the TrkC receptor.
制备了含有两个β-转角模拟物的二价分子,其侧链对应神经营养因子 NT-3 上的热点。结合测定表明模拟物是 TrkC 的选择性配体,生物测定表明其中一种模拟物是 TrkC 受体的拮抗剂。