二价二酮哌嗪基原肌球蛋白受体激酶 C（TrkC）拮抗剂。
Bivalent diketopiperazine-based tropomysin receptor kinase C (TrkC) antagonists.
机构信息
Department of Chemistry, Texas A&M University, Box 30012, College Station, Texas 77842-3012, USA.
出版信息
J Med Chem. 2010 Jul 8;53(13):5044-8. doi: 10.1021/jm100148d.
Abstract
Bivalent molecules containing two beta-turn mimics with side chains that correspond to hot-spots on the neurotrophin NT-3 were prepared. Binding assays showed the mimetics to be selective TrkC ligands, and biological assays showed one mimetic to be an antagonist of the TrkC receptor.
摘要
制备了含有两个β-转角模拟物的二价分子，其侧链对应神经营养因子 NT-3 上的热点。结合测定表明模拟物是 TrkC 的选择性配体，生物测定表明其中一种模拟物是 TrkC 受体的拮抗剂。
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本文引用的文献
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Bivalent peptidomimetic ligands of TrkC are biased agonists and selectively induce neuritogenesis or potentiate neurotrophin-3 trophic signals.TrkC的二价拟肽配体是偏向性激动剂，可选择性诱导神经突生长或增强神经营养因子-3的营养信号。
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