Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Saarland, University, Homburg (Saar), Germany.
Curr Drug Metab. 2010 Jun 1;11(5):468-82. doi: 10.2174/138920010791526042.
This paper reviews the metabolism of new designer drugs of abuse that have emerged on the black market during the last years and is an update of a review published in 2005. The presented review contains data concerning the so-called 2C compounds (phenethylamine type) such as 4-bromo-2,5-dimethoxy-beta-phenethylamine (2C-B), 4-iodo-2,5-dimethoxy-beta-phenethylamine (2C-I), 2,5-dimethoxy-4-methyl-beta-phenethylamine (2C-D), 4-ethyl-2,5-dimethoxy-beta-phenethylamine (2C-E), 4-ethylthio-2,5-dimethoxy-beta-phenethylamine (2C-T-2), and 2,5-dimethoxy-4-propylthio-beta-phenethylamine (2C-T-7), beta-keto designer drugs such as 2-methylamino-1-(3,4-methylenedioxyphenyl)butan-1-one (butylone, bk-MBDB), 2-ethylamino-1-(3,4-methylenedioxyphenyl)propan-1-one (ethylone, bk-MDEA), 2-methylamino-1-(3,4-methylene notdioxy notphenyl)propan-1-one (methylone, bk-MDMA), and 2-methylamino-1-p-tolylpropane-1-one (mephedrone, 4-methyl-methcathinone), pyrrolidino notphenones such as 4-methyl-pyrrolidinobutyrophenone (MPBP) and alpha-pyrrolidinovalerophenone (PVP), phencyclidine-derived drugs such as N (1 phenylcyclohexyl) propanamine (PCPr), N-(1-phenylcyclohexyl)-2-ethoxyethanamine (PCEEA), N-(1-phenylcyclohexyl)-3-methoxypropanamine (PCMPA), and N-(1-phenylcyclohexyl)-2-methoxyethanamine (PCMEA), tryptamines such as 5-methoxy-N,N-diisopropyl nottryptamine (5-MeO-DIPT), and finally alpha-methylfentanyl (alpha-MF) and 3-methylfentanyl (3-MF). Papers have been considered and reviewed on the identification of in vivo or in vitro human or animal metabolites and the cytochrome P450 or monoamineoxidase isoenzyme-dependent metabolism.
本文综述了近年来黑市上出现的新型滥用药物的代谢情况，是对 2005 年发表的一篇综述的更新。本文包含了所谓的 2C 化合物（苯乙胺类），如 4-溴-2,5-二甲氧基-beta-苯乙胺（2C-B）、4-碘-2,5-二甲氧基-beta-苯乙胺（2C-I）、2,5-二甲氧基-4-甲基-beta-苯乙胺（2C-D）、4-乙基-2,5-二甲氧基-beta-苯乙胺（2C-E）、4-乙硫基-2,5-二甲氧基-beta-苯乙胺（2C-T-2）和 2,5-二甲氧基-4-丙基硫代-beta-苯乙胺（2C-T-7）、β-酮类设计药物，如 2-甲基氨基-1-（3,4-亚甲二氧基苯基）丁-1-酮（丁酮，bk-MBDB）、2-乙基氨基-1-（3,4-亚甲二氧基苯基）丙-1-酮（乙酮，bk-MDEA）、2-甲基氨基-1-（3,4-亚甲二氧基苯基）丙烷-1-酮（甲酮，bk-MDMA）和 2-甲基氨基-1-对甲苯基丙烷-1-酮（甲酮，bk-MDMA）和 2-甲基氨基-1-对甲苯基丙烷-1-酮（甲酮，bk-MDMA）和 2-甲基氨基-1-对甲苯基丙烷-1-酮（甲酮，bk-MDMA）和 2-甲基氨基-1-对甲苯基丙烷-1-酮（甲酮，bk-MDMA），吡咯烷酮类如 4-甲基-吡咯烷丁基苯酮（MPBP）和α-吡咯烷戊基苯酮（PVP）、苯环利定衍生药物如 N（1-苯基环己基）丙胺（PCPr）、N-（1-苯基环己基）-2-乙氧基乙胺（PCEEA）、N-（1-苯基环己基）-3-甲氧基丙胺（PCMPA）和 N-（1-苯基环己基）-2-甲氧基乙胺（PCMEA）、色胺类如 5-甲氧基-N,N-二异丙基色胺（5-MeO-DIPT），最后是α-甲基芬太尼（α-MF）和 3-甲基芬太尼（3-MF）。本文综述了体内或体外人类或动物代谢物的鉴定以及细胞色素 P450 或单胺氧化酶同工酶依赖性代谢情况。
