Department of Pharmaceutical Engineering, SunMoon University, # 100, Kalsan-ri, Tangjeong-myeon, Asan-si, Chungnam 336-708, Republic of Korea.
J Biosci Bioeng. 2010 Jul;110(1):109-12. doi: 10.1016/j.jbiosc.2010.01.005. Epub 2010 Feb 4.
Aminoglycoside antibiotics can be classified into two major groups; streptamine containing and 2-deoxystreptamine containing antibiotics. Here, we report a biosynthetic approach for the fusion of spectinomycin and kanamycin biosynthetic gene clusters to yield the new aminoglycoside derivative, oxykanamycinC, in a non-aminoglycoside producing heterologous host.
含链霉胺和含 2-脱氧链霉胺的抗生素。在这里，我们报告了一种生物合成方法，用于融合壮观霉素和卡那霉素生物合成基因簇，以在非氨基糖苷类产生的异源宿主中产生新的氨基糖苷类衍生物氧卡那霉素 C。
