Beckmann H, Jakob H
Department of Psychiatry, University of Würzburg, Federal Republic of Germany.
J Neural Transm Gen Sect. 1991;84(1-2):155-64. doi: 10.1007/BF01249120.
Both types of functional psychosis schizophrenia and manic depressive illness (MDI) share several epidemiological, clinical and genetic characteristics. Subtle morphological changes as evidenced by neuroimaging techniques have also been reported in both entities. Thus far, neuropathological changes have been described in schizophrenia only. We report four cases of MDI with neuropathological changes similar to those found in schizophrenia, i.e. definite disturbances in the cytoarchitecture within the entorhinal region indicating a migrational malformation in the superficial layers possibly originating in the second fetal trimester. A limited sector of the rostro-ventral insula showed a diminution of the nerve cell population. We suggest a vulnerability factor secondary to fetal developmental impairment in the entorhinal region common to both schizophrenia and MDI.
两种功能性精神病——精神分裂症和躁郁症（MDI）具有一些共同的流行病学、临床和遗传特征。神经影像学技术显示，这两种疾病也都存在细微的形态学变化。迄今为止，仅在精神分裂症中描述过神经病理学变化。我们报告了4例MDI病例，其神经病理学变化与精神分裂症中发现的变化相似，即内嗅区细胞结构存在明确紊乱，表明表层可能起源于胎儿中期的迁移畸形。嘴侧腹侧岛叶的一个有限区域显示神经细胞数量减少。我们认为，精神分裂症和MDI共有的内嗅区胎儿发育损伤继发的易损因素。
