Wendland B, Miller K G, Schilling J, Scheller R H
Howard Hughes Medical Institute, Stanford University, California 94305.
Neuron. 1991 Jun;6(6):993-1007. doi: 10.1016/0896-6273(91)90239-v.
The genome of the marine ray Discopyge ommata contains at least three p65-related genes. o-p65-A is 84% identical, o-p65-B is 78% identical, and o-p65-C is only 41% identical to a previously characterized rat p65. The cytoplasmic domain, particularly the two regions that are similar to the regulatory domain of protein kinase C, are most highly conserved. The three genes are expressed in different but overlapping patterns in the central nervous system. o-p65-A immunoreactivity is found predominantly in forebrain, cerebellum, and neuroendocrine cells, while o-p65-B immunoreactivity is predominantly localized to the spinal cord, brainstem, and midbrain. Many synaptic vesicle proteins are members of small gene families that are differentially expressed, resulting in several unique combinations of these molecules in specific brain regions.
海洋鳐鱼圆犁头鳐(Discopyge ommata)的基因组包含至少三个与p65相关的基因。o-p65-A与先前鉴定的大鼠p65有84%的同一性,o-p65-B有78%的同一性,而o-p65-C仅与大鼠p65有41%的同一性。胞质结构域,特别是与蛋白激酶C调节结构域相似的两个区域,是最保守的。这三个基因在中枢神经系统中以不同但重叠的模式表达。o-p65-A免疫反应性主要在前脑、小脑和神经内分泌细胞中发现,而o-p65-B免疫反应性主要定位于脊髓、脑干和中脑。许多突触小泡蛋白是差异表达的小基因家族的成员,导致这些分子在特定脑区有几种独特的组合。