Department of Obstetrics, University of the Region of Joinville (UNIVILLE), Joinville, Brazil.
Int J Gynaecol Obstet. 2010 Oct;111(1):37-40. doi: 10.1016/j.ijgo.2010.04.028. Epub 2010 Jun 14.
To assess blood glucose control and neonatal outcomes when women with gestational diabetes mellitus (GDM) were treated with metformin or glyburide.
When an appropriate diet was insufficient to control their blood glucose levels, women with GDM were randomized to a glyburide or a metformin treatment group. If the maximum dose was reached, the assessed drug was replaced by insulin. The primary outcome measures analyzed were maternal glucose levels during pregnancy, birth weight, and neonatal glucose levels.
The only significant difference in outcome between the 2 treatment drugs was that maternal weight gain during pregnancy was less in the metformin (n=40) than in the glyburide group (n=32) (10.3 kg vs 7.6 kg; P=0.02). No differences were found in treatment failure, mean level of fasting or postprandial plasma glucose, rate of participants with glycated hemoglobin, birth weight, rate of large-for-gestational-age newborns, or newborns with hypoglycemia.
The treatment of GDM with metformin or glyburide was found to be equivalent for both women and newborns.
评估患有妊娠糖尿病（GDM）的女性使用二甲双胍或格列本脲治疗时的血糖控制和新生儿结局。
当适当的饮食不足以控制血糖水平时，GDM 女性被随机分配到格列本脲或二甲双胍治疗组。如果达到最大剂量，则用胰岛素替代评估药物。主要结局指标分析包括妊娠期间的母体血糖水平、出生体重和新生儿血糖水平。
两种治疗药物之间唯一显著的结局差异是，在二甲双胍组（n=40）中，妊娠期间的母体体重增加少于格列本脲组（n=32）（10.3kg 比 7.6kg；P=0.02）。治疗失败、空腹或餐后血浆葡萄糖的平均水平、糖化血红蛋白参与者的比例、出生体重、巨大儿新生儿的比例或低血糖新生儿的比例均无差异。
对于女性和新生儿，使用二甲双胍或格列本脲治疗 GDM 的效果是等效的。
Zotero 插件