Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Phytochemistry. 2010 Aug;71(11-12):1365-70. doi: 10.1016/j.phytochem.2010.05.015. Epub 2010 Jun 11.
Leucofoline and leuconoline, representing the first members of the aspidospermatan-aspidospermatan and eburnane-sarpagine subclasses of the bisindole alkaloids, respectively, were isolated from the Malayan Leuconotis griffithii. The structures of these bisindole alkaloids were established using NMR and MS analysis, and in the case of leuconoline, confirmed by X-ray diffraction analysis. Both alkaloids showed weak cytotoxicity towards human KB cells.
分别来自马来 Leuconotis griffithii 的白叶藤碱和白屈菜碱代表了双吲哚生物碱中的阿皮斯多林-阿皮斯多林和鹅掌楸-撒朴宁亚类的第一个成员。这些双吲哚生物碱的结构是通过 NMR 和 MS 分析确定的，而白屈菜碱的结构则通过 X 射线衍射分析得到了证实。两种生物碱对人 KB 细胞均显示出较弱的细胞毒性。
